Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms232213947
Keywords
acid; duodenal mucosa; epigastric pain syndrome; mucosal vulnerability; transepithelial electrical resistance
Funding
- Japan Society for the Promotion of Science [18K07992]
Ask authors/readers for more resources
An unidentified cause of functional dyspepsia (FD) is closely associated with medication resistance. Acid suppression is a traditional and preferential method for treating FD, but its efficacy varies between epigastric pain syndrome (EPS) and postprandial syndrome (PDS). This study found that the duodenal mucosal transepithelial electrical resistance (TEER) in EPS patients decreased when exposed to acidic solutions, even under weak acidic conditions. The decrease in TEER was correlated with the severity of epigastric pain. Additionally, EPS patients had an increase in mast cells and plasma cells expressing Ig-E in the duodenal mucosa, suggesting that duodenal mucosal vulnerability to acid may contribute to the development of EPS.
An unidentified cause of functional dyspepsia (FD) is closely associated with medication resistance. Acid suppression is a traditional and preferential method for the treatment of FD, but the efficacy of this treatment varies between epigastric pain syndrome (EPS) and postprandial syndrome (PDS): it is efficient in the former but not much in the latter. Transepithelial electrical resistance (TEER), a surrogate of mucosal barrier function, was measured under pH 3 and pH 5 acidic conditions using duodenal biopsy specimens obtained from the patients with EPS and PDS and asymptomatic healthy controls. The infiltration of inflammatory cells to the duodenal mucosa was accessed by immunohistochemical analysis. The duodenal mucosal TEER in EPS patients was decreased by exposure to the acidic solution compared to that of the controls and the PDS patients. The decrease in TEER of the EPS patients was observed even under pH 5 weak acidic condition and was correlated to degree of the epigastric pain. Moreover, the duodenal mucosa of EPS patients presented an increase in mast cells and plasma cells that expressed Ig-E. Duodenal mucosal vulnerability to acid is likely to develop EPS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available