4.7 Article

Vaccine-associated paralytic poliomyelitis in a child: fast transformation from Sabin-like virus to vaccine-derived poliovirus triggered an epidemiological response in two countries of the European region

Journal

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 125, Issue -, Pages 35-41

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2022.09.034

Keywords

AFP; VAPP; Genome analysis; Epidemiological surveillance; Immunization; VDPV

Ask authors/readers for more resources

The study traced the rapid evolution of a Sabin-like poliovirus in a child through repeated stool sampling, highlighting the importance of acute flaccid paralysis surveillance and high vaccination coverage.
Objectives: The detection of a vaccine-derived poliovirus (VDPV) requires an epidemiological assessment and response. Using repeated stool sampling from a child who is immunocompetent and was vaccinated against poliomyelitis with acute flaccid paralysis, a case of an extremely rapid evolution of Sabin-like poliovirus (PV) type 3 was traced in the child's body.Methods: The case was independently identified in two countries-Tajikistan and Russia. Stool samples for the study were also independently collected in two countries on different days from the onset of paraly-sis. Virological, serological, and molecular methods; full genome Sanger; and high-throughput sequencing were performed to characterize isolates.Results: PV isolates from samples collected on days 2, 3, and 14 contained eight, seven, and seven mu-tations in the VP1-coding region, respectively, and were classified as Sabin-like PV type 3. The isolates from samples collected on days 15 and 18 had 11 mutations and were classified as vaccine-derived PVs, which required an epidemiological response in the two countries.Conclusion: The results indicate the need to continue acute flaccid paralysis surveillance, maintain high vaccination coverage, and develop and introduce new effective, genetically stable PV vaccines.(c) 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available