Effectiveness and safety of b e daquiline-base d, modifie d all-oral 9-11-month treatment regimen for rifampicin-resistant tuberculosis in Vietnam

Article Immunology

Safety and Effectiveness of an All-Oral, Bedaquiline-Based, Shorter Treatment Regimen for Rifampicin-Resistant Tuberculosis in High Human Immunodeficiency Virus (HIV) Burden Rural South Africa: A Retrospective Cohort Analysis

Ilse Tack et al.

Summary: This study evaluated the safety and effectiveness of an all-oral treatment regimen containing BDQ and LZD for RR-TB patients in a rural setting in South Africa. The results showed good treatment outcomes but also common adverse events, especially for LZD, which could be managed in the program setting with support for staff training in monitoring, management, and reporting of adverse events.

CLINICAL INFECTIOUS DISEASES (2021)

Add to Collection

Article Respiratory System

World Health Organization recommendations on the treatment of drug-resistant tuberculosis, 2020 update

Fuad Mirzayev et al.

Summary: Antimicrobial resistance is a significant global public health issue, as is the challenge posed by drug-resistant forms of tuberculosis. The World Health Organization has recently updated their guidelines for the treatment of MDR and RR TB, recommending shorter, all-oral regimens and emphasizing the importance of individualized treatment plans.

EUROPEAN RESPIRATORY JOURNAL (2021)

Add to Collection

Article Infectious Diseases

Insignificant difference in culture conversion between bedaquiline-containing and bedaquiline-free all-oral short regimens for multidrug-resistant tuberculosis

Liang Fu et al.

Summary: This study evaluated two optimized all-oral short-course regimens for MDR-TB patients in China and found satisfactory efficacy and safety in the early treatment stage. Further research is needed to confirm these results.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Infectious Diseases

Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis

Richard Court et al.

Summary: A high incidence of early neuropsychiatric toxicity was observed in patients treated with terizidone, with neuropathy being independently associated with cycloserine clearance and high-dose pyridoxine.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Respiratory System

Effectiveness and safety of fully oral modified shorter treatment regimen for multidrug-resistant tuberculosis in Georgia, 2019-2020

Teona Avaliani et al.

Summary: The study in Georgia evaluated the effectiveness and safety of a modified shorter treatment regimen for rifampicin-resistant tuberculosis patients sensitive to fluoroquinolone. The regimen showed good treatment outcomes and was well tolerated, indicating potential for wider use in high priority countries.

MONALDI ARCHIVES FOR CHEST DISEASE (2021)

Add to Collection

Article Medicine, General & Internal