Journal
INTERNATIONAL JOURNAL OF CHEMICAL KINETICS
Volume 55, Issue 3, Pages 119-128Publisher
WILEY
DOI: 10.1002/kin.21622
Keywords
2; 2-aminobenzamide; 3-dihydroquinazolin-4(1H)-ones; dioxomolybdenum(VI) complex; Quinazolin-4(3H)-ones; Schiff base
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In this study, a novel and practical method was reported for the selective synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones via condensation of 2-aminobenzamide with aldehydes or ketones, using a Schiff base dioxomolybdenum(VI) complex as an efficient catalyst with low loading (0.5% mol). Additionally, this catalyst was also found to be efficient for the construction of quinazolin-4(3H)-ones in the presence of hydrogen peroxide, through an oxidative cyclization reaction at higher temperature.
Schiff base dioxomolybdenum(VI) complex is found to be a novel and efficient catalyst for the selective synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-ones via condensation of 2-aminobenzamide with aldehydes or ketones. Also, this catalyst is also found to be efficient for the construction of quinazolin-4(3H)-ones while in the presence of hydrogen peroxide as oxidant. At higher temperature the aldehydes undergo an oxidative cyclization reaction affording the quinazolin-4(3H)-ones. Herein we report a novel protocol with practical simplicity, broad substrate scope, good selectivity, moderate to excellent yields, and low catalyst loading (0.5% mol).
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