Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 222, Issue -, Pages 30-40Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.09.054
Keywords
Directional freeze-drying; Hemostatic dressings; ColMA; HAMA sponge
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This study presents a feasible strategy to construct a rapid hemostatic sponge for deep and non-compressible perforating wounds. The sponge, based on methacrylated collagen and hyaluronate, demonstrated excellent mechanical strength and superior blood clotting capacity in vitro and in a rat-liver injury model.
Uncontrolled hemorrhage of deep, narrow, and non-compressible perforating wounds is responsible for many trauma deaths. In this study, a rapid hemostatic sponge with an orderly channel based on methacrylated collagen (ColMA) was prepared via directional freeze-drying technology. The methacrylated hyaluronate (HAMA) was added to further enhance the mechanical properties of the sponge. The sponge presents excellent mechanical strength, rapid shape recovery, and absorption speed, which was faster than those of many reported natural polymer hemostatic sponges. Moreover, ColMA/HAMA sponge showed much better blood-clotting capacity and superior hemostasis performance than commercially available collagen sponges in vitro and in the rat-liver injury model. This study demonstrated a feasible strategy to construct the rapid hemostatic sponge with an orderly channel for the deep and non-compressible perforating wound.
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