Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 225, Issue -, Pages 90-102Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.12.024
Keywords
Biomimetic; Multifunctional dressing; Antibacterial; Enzymatic cross-linking; Burn wound
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A multifunctional hybrid sponge dressing with good wet adhesion was developed by combining biomimetic and enzymatic cross-linking reactions. The dressing exhibited high mechanical properties, antibacterial activity, ROS scavenging, biocompatibility, and excellent hemostasis ability. In vivo studies showed that it could significantly accelerate the healing of infected full-thickness burn wounds.
Preparing sponge dressings with stable wet adhesion remains difficult in wound repair, especially in burn wounds with bleeding and large amounts of exudate. In this work, a multifunctional hybrid sponge dressing (DHGT+PHMB+TiO2NPs) with good wet adhesion was developed by combining biomimetic and enzymatic cross-linking reactions. The sponge dressing matrix (DHGT) was prepared by tyrosinase-catalyzed cross-linking of dopamine-modified hyaluronic acid (DOPA-HA) and gelatin. The multifunctional hybrid sponge dressing was obtained by loading polyhexamethylene biguanide (PHMB) and titanium dioxide nanoparticles (TiO2NPs) onto the DHGT matrix. The newly developed sponge dressing exhibited high mechanical properties, good wet adhesion, antibacterial activity, reactive oxygen species (ROS) scavenging, biocompatibility, and excellent he-mostasis ability. In vivo studies showed that the multifunctional hybrid sponge dressing could significantly accelerate the healing of infected full-thickness burn wounds by inhibiting bacterial growth, accelerating skin tissue reepithelialization, collagen deposition, and angiogenesis, as well as regulating the expression of in-flammatory factors and cytokines.
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