Related references
Note: Only part of the references are listed.Growth and Differentiation Factor-5 Contributes to the Structural and Functional Maintenance of the Intervertebral Disc
Chencheng Feng et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
Interleukin-1β in intervertebral disk degeneration
Wei Yang et al.
CLINICA CHIMICA ACTA (2015)
Prolyl-4-hydroxylase Domain Protein 2 Controls NF-kappa B/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus
Jun Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Age-Dependency of Glycosaminoglycan Content in Lumbar Discs: A 3T gagCEST Study
Anja Mueller-Lutz et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2015)
MRI evaluation of spontaneous intervertebral disc degeneration in the alpaca cervical spine
Dean K. Stolworthy et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2015)
Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes
K. L. E. Phillips et al.
OSTEOARTHRITIS AND CARTILAGE (2015)
ISSLS Prize Winner: Vertebral Endplate (Modic) Change is an Independent Risk Factor for Episodes of Severe and Disabling Low Back Pain
Juhani H. Maatta et al.
SPINE (2015)
Low rate loading-induced convection enhances net transport into the intervertebral disc in vivo
Sarah E. Gullbrand et al.
SPINE JOURNAL (2015)
Harnessing the Potential of Mesenchymal Stem Cells for IVD Regeneration
Louise E. Clarke et al.
CURRENT STEM CELL RESEARCH & THERAPY (2015)
OXIDATIVE STRESS INHIBITS THE PROLIFERATION, INDUCES PREMATURE SENESCENCE AND PROMOTES A CATABOLIC PHENOTYPE IN HUMAN NUCLEUS PULPOSUS INTERVERTEBRAL DISC CELLS
A. Dimozi et al.
EUROPEAN CELLS & MATERIALS (2015)
Tumor Necrosis Factor-α and Interleukin-1β-Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase NF-κB Axis Implications in Inflammatory Disc Disease
Xin Wang et al.
AMERICAN JOURNAL OF PATHOLOGY (2014)
Expression of Matrix Metalloproteinases is Positively Related to the Severity of Disc Degeneration and Growing Age in the East Asian Lumbar Disc Herniation Patients
Haidong Xu et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
Influence of maturity on nucleus-endplate integration in the ovine lumbar spine
Kelly R. Wade et al.
EUROPEAN SPINE JOURNAL (2014)
Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress
Jong-Soo Park et al.
INTERNATIONAL ORTHOPAEDICS (2014)
The aging mouse partially models the aging human spine: lumbar and coccygeal disc height, composition, mechanical properties, and Wnt signaling in young and old mice
Nilsson Holguin et al.
JOURNAL OF APPLIED PHYSIOLOGY (2014)
FIH-1-Mint3 Axis Does Not Control HIF-1α Transcriptional Activity in Nucleus Pulposus Cells
Yuichiro Hirose et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Is post-contrast MRI a valuable method for the study of the nutrition of the intervertebral disc?
Fabio Galbusera et al.
JOURNAL OF BIOMECHANICS (2014)
Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression
Qiaoqiao Zhu et al.
JOURNAL OF BIOMECHANICS (2014)
The Catabolic Effect of TNFα on Bovine Nucleus Pulposus Intervertebral Disc Cells and the Restraining Role of Glucosamine Sulfate in the TNFα-Mediated up-Regulation of MMP-3
Eleni Mavrogonatou et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2014)
The role of senescent cells in ageing
Jan M. van Deursen
NATURE (2014)
Role of cytokines in intervertebral disc degeneration: pain and disc content
Makarand V. Risbud et al.
NATURE REVIEWS RHEUMATOLOGY (2014)
Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP
Zariel I. Johnson et al.
MATRIX BIOLOGY (2014)
Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products
Alfonso Gautieri et al.
MATRIX BIOLOGY (2014)
The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence
Mehtap Kilic Eren et al.
PLOS ONE (2014)
Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus
Christophe Merceron et al.
PLOS ONE (2014)
Simulation of the Progression of Intervertebral Disc Degeneration Due to Decreased Nutritional Supply
Weiyong Gu et al.
SPINE (2014)
Investigating the role of DNA damage in tobacco smoking-induced spine degeneration
Luigi A. Nasto et al.
SPINE JOURNAL (2014)
Link N and Mesenchymal Stem Cells Can Induce Regeneration of the Early Degenerate Intervertebral Disc
Fackson Mwale et al.
TISSUE ENGINEERING PART A (2014)
EPIGALLOCATECHIN 3-GALLATE SUPPRESSES INTERLEUKIN-1β-INDUCED INFLAMMATORY RESPONSES IN INTERVERTEBRAL DISC CELLS IN VITRO AND REDUCES RADICULOPATHIC PAIN IN RATS
O. Krupkova et al.
EUROPEAN CELLS & MATERIALS (2014)
Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB
Ye Tian et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration
Kate Louise Eve Phillips et al.
ANNALS OF THE RHEUMATIC DISEASES (2013)
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
Ana P. Gomes et al.
CELL (2013)
Age-Related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification
Brian Scharf et al.
CHEMISTRY & BIOLOGY (2013)
Effect of intervertebral disc degeneration on disc cell viability: a numerical investigation
Fabio Galbusera et al.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2013)
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Tamara Tchkonia et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Dystrophin and utrophin double knockout dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities
Christian Isaac et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2013)
Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration
Luigi A. Nasto et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2013)
An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints
Nam Vo et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2013)
Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs
Luigi A. Nasto et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2013)
Intervertebral Disc Decompression Following Endplate Damage Implications for Disc Degeneration Depend on Spinal Level and Age
Patricia Dolan et al.
SPINE (2013)
Injection of human umbilical tissue-derived cells into the nucleus pulposus alters the course of intervertebral disc degeneration in vivo
Steven K. Leckie et al.
SPINE JOURNAL (2013)
Ionizing radiation exposure and the development of intervertebral disc degeneration-no case to answer
Fiona E. Mellor et al.
SPINE JOURNAL (2013)
Cells from Degenerative Intervertebral Discs Demonstrate Unfavorable Responses to Mechanical and Inflammatory Stimuli A Pilot Study
Gwendolyn A. Sowa et al.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION (2012)
The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: A population-based study
Dino Samartzis et al.
ARTHRITIS AND RHEUMATISM (2012)
Is the spinal motion segment a diarthrodial polyaxial joint: What a nice nucleus like you doing in a joint like this?
Irving M. Shapiro et al.
BONE (2012)
Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc DISTINCT ROLES OF PHD2 AND PHD3 PROTEINS IN CONTROLLING HIF-1α ACTIVITY IN HYPOXIA
Nobuyuki Fujita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling
Nobuyuki Fujita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Quantitative analysis of exogenous IGF-1 administration of intervertebral disc through intradiscal injection
C. -Y. Huang et al.
JOURNAL OF BIOMECHANICS (2012)
Novel ex-vivo mechanobiological intervertebral disc culture system
Robert A. Hartman et al.
JOURNAL OF BIOMECHANICS (2012)
HIF-1a and HIF-2a degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc
Nobuyuki Fujita et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2012)
NF-κB inhibition delays DNA damage-induced senescence and aging in mice
Jeremy S. Tilstra et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity
Marina Klawitter et al.
JOURNAL OF INFLAMMATION-LONDON (2012)
Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways
Harris Pratsinis et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
Fracture of the vertebral endplates, but not equienergetic impact load, promotes disc degeneration in vitro
Stefan Dudli et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
Oxidative Damage, Platelet Activation, and Inflammation to Predict Mobility Disability and Mortality in Older Persons: Results From the Health Aging and Body Composition Study
Matteo Cesari et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)
Increased intramuscular fatty infiltration without differences in lumbar muscle cross-sectional area during remission of unilateral recurrent low back pain
Roseline D'hooge et al.
MANUAL THERAPY (2012)
MAMMALIAN MAPK SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION: A 10-YEAR UPDATE
John M. Kyriakis et al.
PHYSIOLOGICAL REVIEWS (2012)
Spine degeneration in a murine model of chronic human tobacco smokers
D. Wang et al.
OSTEOARTHRITIS AND CARTILAGE (2012)
Part 2: Quantitative Proton T2 and Sodium Magnetic Resonance Imaging to Assess Intervertebral Disc Degeneration in a Rabbit Model
Chan Hong Moon et al.
SPINE (2012)
ISSLS Prize Winner: Inhibition of NF-κB Activity Ameliorates Age-Associated Disc Degeneration in a Mouse Model of Accelerated Aging
Luigi A. Nasto et al.
SPINE (2012)
The Dog as an Animal Model for Intervertebral Disc Degeneration?
Niklas Bergknut et al.
SPINE (2012)
Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model
Steven K. Leckie et al.
SPINE JOURNAL (2012)
Height and torsional stiffness are most sensitive to annular injury in large animal intervertebral discs
Arthur J. Michalek et al.
SPINE JOURNAL (2012)
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
Daisuke Sakai et al.
NATURE COMMUNICATIONS (2012)
Effects of Advanced Age on the Morphometry and Degenerative State of the Cervical Spine in A Rat Model
Andrew C. Laing et al.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2011)
Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
Gregory Livshits et al.
ANNALS OF THE RHEUMATIC DISEASES (2011)
Hypoxic Regulation of β-1,3-Glucuronyltransferase 1 Expression in Nucleus Pulposus Cells of the Rat Intervertebral Disc Role of Hypoxia-Inducible Factor Proteins
Shilpa S. Gogate et al.
ARTHRITIS AND RHEUMATISM (2011)
Notochordal Cells in the Adult Intervertebral Disc: New Perspective on an Old Question
Makarand V. Risbud et al.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION (2011)
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
Adam Freund et al.
EMBO JOURNAL (2011)
Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms
Hongsik Cho et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2011)
Human Intervertebral Disc Internal Strain in Compression: The Effect of Disc Region, Loading Position, and Degeneration
Grace D. O'Connell et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2011)
ADAMTS-5 and Intervertebral Disc Degeneration: The Results of Tissue Immunohistochemistry and In Vitro Cell Culture
Chang-Qing Zhao et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2011)
Longitudinal Study of Radiographic Spinal Osteoarthritis in a Macaque Model
Andrea E. Duncan et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Region-Dependent Aggrecan Degradation Patterns in the Rat Intervertebral Disc Are Affected by Mechanical Loading In Vivo
James C. Iatridis et al.
SPINE (2011)
Direct Application of the Tumor Necrosis Factor-α Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons
Manato Horii et al.
SPINE (2011)
Age-Related Variation in Cell Density of Human Lumbar Intervertebral Disc
Thomas Liebscher et al.
SPINE (2011)
Expression of silent mating type information regulator 2 homolog 1 and its role in human intervertebral disc cell homeostasis
Zhongying Zhang et al.
ARTHRITIS RESEARCH & THERAPY (2011)
AGING AFFECTS RESPONSE TO CYCLIC TENSILE STRETCH: PARADIGM FOR INTERVERTEBRAL DISC DEGENERATION
Hongsik Cho et al.
EUROPEAN CELLS & MATERIALS (2011)
Hypoxic Regulation of Nucleus Pulposus Cell Survival From Niche to Notch
Makarand V. Risbud et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Enhancement of Intervertebral Disc Cell Senescence by WNT/β-Catenin Signaling-Induced Matrix Metalloproteinase Expression
Akihiko Hiyama et al.
ARTHRITIS AND RHEUMATISM (2010)
Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
Helen E. Gruber et al.
BMC BIOTECHNOLOGY (2010)
Comparative anatomical dimensions of the complete human and porcine spine
Iris Busscher et al.
EUROPEAN SPINE JOURNAL (2010)
Analysis of cell viability in intervertebral disc: Effect of endplate permeability on cell population
A. Shirazi-Adl et al.
JOURNAL OF BIOMECHANICS (2010)
Multipotential Differentiation of Human Anulus Fibrosus Cells An in Vitro Study
Gang Feng et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2010)
Accelerated Aging of Intervertebral Discs in a Mouse Model of Progeria
Nam Vo et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2010)
Effect of Varying Osmotic Conditions on the Response of Bovine Nucleus Pulposus Cells to Growth Factors and the Activation of the ERK and Akt Pathways
Eleni Mavrogonatou et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2010)
Leg Amputation Accelerates Senescence of Rat Lumbar Intervertebral Discs
Qiu-Juan Xing et al.
SPINE (2010)
The Effects of Exogenous Crosslinking on Hydration and Fluid Flow in the Intervertebral Disc Subjected to Compressive Creep Loading and Unloading
Shih-Youeng Chuang et al.
SPINE (2010)
Isolation and Characterization of Mesenchymal Stromal Cells From Human Degenerated Nucleus Pulposus Comparison With Bone Marrow Mesenchymal Stromal Cells From the Same Subjects
Juan F. Blanco et al.
SPINE (2010)
MAPK signaling in inflammation-associated cancer development
Pengyu Huang et al.
PROTEIN & CELL (2010)
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
Ludmila Pawlikowska et al.
AGING CELL (2009)
Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis
James C. Iatridis et al.
CELLULAR AND MOLECULAR BIOENGINEERING (2009)
Pericellular Matrix Mechanics in the Anulus Fibrosus Predicted by a Three-Dimensional Finite Element Model and In Situ Morphology
Li Cao et al.
CELLULAR AND MOLECULAR BIOENGINEERING (2009)
Stress-Activated MAP Kinase Cascades in Cellular Senescence
Junichi Maruyama et al.
CURRENT MEDICINAL CHEMISTRY (2009)
High osmolality activates the G1 and G2 cell cycle checkpoints and affects the DNA integrity of nucleus pulposus intervertebral disc cells triggering an enhanced DNA repair response
Eleni Mavrogonatou et al.
DNA REPAIR (2009)
In Vivo Remodeling of Intervertebral Discs in Response to Short- and Long-Term Dynamic Compression
Karin Wuertz et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2009)
Intervertebral Disc Cell Response to Dynamic Compression Is Age and Frequency Dependent
Casey L. Korecki et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2009)
Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?
Judith Campisi et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)
Ageing populations: the challenges ahead
Kaare Christensen et al.
LANCET (2009)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
NATURE CELL BIOLOGY (2009)
Impact of Chronic Musculoskeletal Pathology on Older Adults: A Study of Differences between Knee OA and Low Back Pain
Natalia E. Morone et al.
PAIN MEDICINE (2009)
Absence of Biglycan Accelerates the Degenerative Process in Mouse Intervertebral Disc
Takashi Furukawa et al.
SPINE (2009)
Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc
Kern Singh et al.
SPINE (2009)
Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
Ki-Won Kim et al.
SPINE JOURNAL (2009)
Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus
Helen E. Gruber et al.
SPINE JOURNAL (2009)
Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner et al.
NATURE REVIEWS CANCER (2009)
Cited2 Modulates Hypoxia-Inducible Factor-Dependent Expression of Vascular Endothelial Growth Factor in Nucleus Pulposus Cells of the Rat Intervertebral Disc
Amit Agrawal et al.
ARTHRITIS AND RHEUMATISM (2008)
Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration
R. Ali et al.
BIOTECHNIC & HISTOCHEMISTRY (2008)
Chemokine signaling via the CXCR2 receptor reinforces senescence
Juan C. Acosta et al.
CELL (2008)
Mitochondria - A nexus for aging, calorie restriction, and sirtuins?
Leonard Guarente
CELL (2008)
Growth factors in intervertebral disc homeostasis
Harris Pratsinis et al.
CONNECTIVE TISSUE RESEARCH (2008)
Gene therapy approach for disc degeneration and associated spinal disorders
Kotaro Nishida et al.
EUROPEAN SPINE JOURNAL (2008)
Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan
Laura J. Niedemhofer et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1
Rebecca K. Studer et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2008)
Mitogen-activated protein (MAP) Kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer
Tarek Boutros et al.
PHARMACOLOGICAL REVIEWS (2008)
Characterization of intervertebral disc aging -: Longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression
Gwendolyn Sowa et al.
SPINE (2008)
The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc
Xin Li et al.
SPINE (2008)
Autophagy and aging: keeping that old broom working
Ana Maria Cuervo
TRENDS IN GENETICS (2008)
Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration
Sarah Kathleen Heathfield et al.
ARTHRITIS RESEARCH & THERAPY (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
Vertebral endplate trauma induces disc cell apoptosis and promotes organ degeneration in vitro
Daniel Haschtmann et al.
EUROPEAN SPINE JOURNAL (2008)
Motif module map reveals enforcement of aging by continual NF-κB activity
Adam S. Adler et al.
GENES & DEVELOPMENT (2007)
HIF-1α is a regulator of galectin-3 expression in the intervertebral disc
Yan Zeng et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2007)
Evidence for skeletal progenitor cells in the degenerate human intervertebral disc
Makarand V. Risbud et al.
SPINE (2007)
PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways
Harris Pratsinis et al.
EUROPEAN SPINE JOURNAL (2007)
Vertebral Endplate and disc changes in the aging sand rat lumbar spine - Cross-sectional analyses of a large male and female population
Helen E. Gruber et al.
SPINE (2007)
The cell biology of intervertebral disc aging and degeneration
Chang-Qing Zhao et al.
AGEING RESEARCH REVIEWS (2007)
Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk
Amit Agrawal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Measurements of proteoglycan and water content distribution in human lumbar intervertebral discs
James C. Iatridis et al.
SPINE (2007)
Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue
Koichi Sairyo et al.
SPINE (2007)
Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
Swarnali Acharyya et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The effects of anthropometrics, lifting strength, and physical activities in disc degeneration
Tapio Videman et al.
SPINE (2007)
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
Christine Lyn Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2007)
Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1 beta and TNF alpha expression profile
Christine Lyn Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2007)
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Laura J. Niedernhofer et al.
NATURE (2006)
HIF1α delays premature senescence through the activation of MIF
Scott M. Welford et al.
GENES & DEVELOPMENT (2006)
Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs
Sarit Sara Sivan et al.
BIOCHEMICAL JOURNAL (2006)
What is intervertebral disc degeneration, and what causes it?
Michael A. Adams et al.
SPINE (2006)
Senescence in human intervertebral discs
S. Roberts et al.
EUROPEAN SPINE JOURNAL (2006)
Genetics of disc degeneration
Danny Chan et al.
EUROPEAN SPINE JOURNAL (2006)
Nucleus pulposus cells express HIF-1α under normoxic culture conditions:: A metabolic adaptation to the intervertebral disc microenvironment
MV Risbud et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
Antioxidant α-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-κB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-κB ligand and tumor necrosis factor-α
Hyon Jong Kim et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration
CL Le Maitre et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2006)
Glycation increases human annulus fibrosus stiffness in both experimental measurements and theoretical predictions
DR Wagner et al.
JOURNAL OF BIOMECHANICS (2006)
Mechanobiology of the intervertebral disc and relevance to disc degeneration
LA Setton et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2006)
A novel murine gene, Sickle tail, linked to the Danforth's short tail locus, is required for normal development of the intervertebral disc
K Semba et al.
GENETICS (2006)
The elastic fiber network of the anulus fibrosus of the normal and scoliotic human intervertebral disc
J Yu et al.
SPINE (2005)
Metabolism of the intervertebral disc: Effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells
SRS Bibby et al.
SPINE (2005)
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
J Campisi
CELL (2005)
2004 Young Investigator Award winner: Vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration
LM Benneker et al.
SPINE (2005)
The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
CL Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2005)
Experimental disc degeneration due to endplate injury
S Holm et al.
JOURNAL OF SPINAL DISORDERS & TECHNIQUES (2004)
Effect of nutrient deprivation on the viability of intervertebral disc cells
SRS Bibby et al.
EUROPEAN SPINE JOURNAL (2004)
Mechanical conditions that accelerate intervertebral disc degeneration:: Overload versus immobilization
IAF Stokes et al.
SPINE (2004)
Cell mechanics and mechanobiology in the intervertebral disc
LA Setton et al.
SPINE (2004)
Biology of intervertebral disc aging and degeneration - Involvement of the extracellular matrix
PJ Roughley
SPINE (2004)
Aging theories of primary osteoarthritis: From epidemiology to molecular biology
T Aigner et al.
REJUVENATION RESEARCH (2004)
Biomechanics of the aging spine
SJ Ferguson et al.
EUROPEAN SPINE JOURNAL (2003)
Aging and genome maintenance: Lessons from the mouse?
P Hasty et al.
SCIENCE (2003)
Classification of age-related changes in lumbar intervertebral discs
N Boos et al.
SPINE (2002)
The role of the physicochemical environment in determining disc cell behaviour
JPG Urban
BIOCHEMICAL SOCIETY TRANSACTIONS (2002)
The role of proteoglycans in aging, degeneration and repair of the intervertebral disc
PJ Roughley et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2002)
The characterization of versican and its message in human articular cartilage and intervertebral disc
R Sztrolovics et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2002)
Mechanisms of age-related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells
S Okuda et al.
SPINE (2001)
Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation
WEB Johnson et al.
CONNECTIVE TISSUE RESEARCH (2001)
Direction-dependent constriction flow in a poroelastic solid: The intervertebral disc valve
DC Ayotte et al.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME (2000)
Oxidants, oxidative stress and the biology of ageing
T Finkel et al.
NATURE (2000)
Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite
CD Reiter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mobility difficulties and physical activity as predictors of mortality and loss of independence in the community-living older population
M Hirvensalo et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2000)
Changes with age in proteoglycan synthesis in cells cultured in vitro from the inner and outer rabbit annulus fibrosus -: Responses to interleukin-1 and interleukin-1 receptor antagonist protein
S Maeda et al.
SPINE (2000)