Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 229, Issue -, Pages 443-451Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.12.303
Keywords
Chitosan; Adhesive hydrogel; Photocrosslinking
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A novel mussel-inspired adhesive hydrogel, composed of methacrylated catechol-chitosan (MCCS) and dopamine methacrylate (DMA), was synthesized through photopolymerization. The structure and morphology of the MCCS/DMA adhesive hydrogel were characterized by FTIR, NMR, XRD, TG, and SEM. Rheological and texture properties, swelling and degradation characteristics, as well as the adhesion mechanism of the hydrogels were investigated. The results demonstrated the potential applications of the MCCS/DMA adhesive hydrogel in medical bioadhesives.
A novel mussel-inspired adhesive hydrogel with enhanced adhesion based on methacrylated catechol-chitosan (MCCS) and dopamine methacrylate (DMA) was prepared via photopolymerization. The structure and morphology of the MCCS/DMA adhesive hydrogel were investigated by using FTIR, NMR, XRD, TG, and SEM. The rheological and texture properties, swelling and degradation characteristics, as well as the adhesion mechanism of the hydrogels were also examined. These results revealed that the MCCS/DMA hydrogels have a dense double cross-linking network structure with porous internal microstructures, and exhibited controllable swelling and degradation properties, good thermostability, and stable rheological characteristics. Furthermore, the adhesive mechanism of MCCS/DMA hydrogel has been confirmed by the FTIR and 2D correlation FTIR spectroscopy. Additionally, the results of in vitro cytotoxicity assessment indicated that the resulting hydrogels have good cytocompatibility. Overall, the MCCS/DMA adhesive hydrogel may have potential applications in medical bioadhesives.
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