Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 227, Issue -, Pages 424-436Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.12.149
Keywords
Assam bora rice starch; Citrated starch; Physicochemical attributes; Packing and rearrangement behaviour; Disintegration efficiency; Dissolution efficiency
Ask authors/readers for more resources
The current work aims to study the physicochemical attributes, tablet disintegration and dissolution efficiency of starch and its derivatives obtained from the glutinous Assam bora rice (G-ABR) variety of Assam, Northeast India. Starch was isolated using a protein denaturation method and a starch derivative was prepared through citric acid modification. G-ABRS and citrated G-ABRS showed better packing rearrangement and cohesive properties than standard corn starch, indicating their potential as functional excipients in pharmaceutical industries.
The current work was designed to study the starch's physicochemical attributes, tablet disintegration and dissolution efficiency and its derivatives obtained from the glutinous Assam bora rice (G-ABR) variety of Assam, Northeast India. Starch was isolated by a simple protein denaturation method, and a starch derivative was prepared through citric acid modification. G-ABRS and citrated G-ABRS were characterized through FTIR, DSC, XRD and SEM. The rate of consolidation, consolidation index, angle of internal friction, packing rearrangement and cohesive properties were determined to investigate their applications as functional excipients in pharma-ceutical industries. G-ABRS and citrated G-ABRS exhibited better packing rearrangement and cohesive properties than standard corn starch. Furthermore, immediate release of API from the tablet compact was observed when the starch concentration increased from 1 to 5 %, indicating facilitation of the tablet compact disintegration. Therefore, G-ABRS and citrated G-ABRS are potentially functional and sustainable materials for pharmaceutical industries.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available