Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

Article Polymer Science

Facile synthesis and in vitro evaluation of semi-interpenetrating polymeric network

Nadiah Zafar et al.

Summary: This study reported the use of HPMC/AA hydrogel loaded with AZA for the treatment of Crohn's disease, and demonstrated the potential application of HPMC/AA hydrogel for colon targeting of AZA.

POLYMER BULLETIN (2023)

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Article Biophysics

Enhanced photothermal and chemotherapy of pancreatic tumors by degrading the extracellular matrix

Yuancun Cheng et al.

Summary: This study demonstrates a feasible strategy to enhance the permeability of nanoparticles to pancreatic tumors. By synthesizing polypyrrole nanoparticles (PPy NPs) and loading the anticancer drug doxorubicin (DOX) within them, the release of DOX is intelligently controlled using a thermoresponsive ligand lauric acid (LA). The grafting of bromelain (BL) onto the surface of PPy-LA NPs or PPy-LA/DOX NPs enhances the permeability of DOX to pancreatic tumors. Moreover, the resulting PLB NPs also exhibit photothermal conversion and photoacoustic imaging capabilities, enabling imaging-guided tumor ablation.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Biophysics

Sodium alginate hydrogel containing platelet-rich plasma for wound healing

Ting Wang et al.

Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.

COLLOIDS AND SURFACES B-BIOINTERFACES (2023)

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Article Chemistry, Multidisciplinary

Stretchable Unsymmetrical Piezoelectric BaTiO3 Composite Hydrogel for Triboelectric Nanogenerators and Multimodal Sensors

Zhuo Wang et al.

Summary: In this study, a flexible, stretchable, and highly transparent TENG is designed and fabricated based on an unsymmetrical PAM/BTO composite film. By adjusting the amount and distribution location of BTO, the output performance of the TENG can be improved. The TENG also functions as a high-sensitivity pressure sensor that can distinguish a spectrum of forces at the low frequency.

ACS NANO (2022)

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Article Biochemical Research Methods

Multifunctional Nanozyme Hydrogel with Mucosal Healing Activity for Single-Dose Ulcerative Colitis Therapy

Chaoqun Cheng et al.

Summary: A multifunctional nanozyme hydrogel has been designed to scavenge ROS and promote mucosal healing in the treatment of UC, showing better efficacy than the conventional medication 5-aminosalicylic acid. The study highlights the potential of nanozymes in providing mucosal healing for UC therapy, enriching the research landscape in the field of nanomedicine.

BIOCONJUGATE CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

SHARP hydrogel for the treatment of inflammatory bowel disease

Lenka Polakova et al.

Summary: Inflammatory bowel disease (IBD) is a global inflammatory disease affecting millions of people. A new hydrogel system utilizing an antioxidant polymer has shown promising results in treating acute colitis in mice models, offering a potential strategy for IBD treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Oligochitosan Synthesized by Cunninghamella elegans, a Fungus from Caatinga (The Brazilian Savanna) Is a Better Antioxidant than Animal Chitosan

Weslley Souza Paiva et al.

Summary: Animal chitosan (Chit-A) is a popular material in daily activities, but has low antioxidant activity. Fungal oligochitosan (OChit-F), extracted from the fungus Cunninghamella elegans, was found to have higher antioxidant activity than Chit-A and did not induce the formation of calcium oxalate crystals.

MOLECULES (2022)

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Review Neurosciences

Neural signalling of gut mechanosensation in ingestive and digestive processes

Minyoo Kim et al.

Summary: Eating and drinking generate sequential mechanosensory signals along the digestive tract, which are important for the proper intake and digestion of nutrients and water. Recent discoveries of specific mechanoreceptors, ion channels, and neural circuits have expanded our understanding of these processes.

NATURE REVIEWS NEUROSCIENCE (2022)

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Article Nanoscience & Nanotechnology

Rutin-Loaded Stimuli-Responsive Hydrogel for Anti-Inflammation

Hongyue Wang et al.

Summary: An active flavonoid compound, rutin, was incorporated into a guanosine phenylborate hydrogel (GBR) for the treatment of inflammatory bowel disease (IBD). The hydrogel exhibited good stability and injectability, and achieved dual-responsive release in an acidic pH and excessive ROS-containing medium. In vivo studies showed that the GBR hydrogel had higher therapeutic efficacy than free rutin and could suppress the expression of inflammatory cytokines.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

Yingzheng Zhao et al.

Summary: In this study, a double-network hydrogel (PMSP) was developed for the targeted therapy of ulcerative colitis (UC). PMSP showed specific adhesion to the inflamed mucosa and exhibited good mechanical strength and bio-adhesive force. The treatment with PMSP-KPV improved colitis symptoms, promoted the recovery of the colonic epithelial barrier, and modulated the gut flora.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Genetically engineered pH-responsive silk sericin nanospheres with efficient therapeutic effect on ulcerative colitis

Sheng Xu et al.

Summary: This study reports the development of a silk sericin nanosphere system for the delivery of lactoferrin to treat ulcerative colitis. The system demonstrated stable morphology, specific targeting to colonic sites, and efficient cell uptake. Oral administration of the system effectively relieved symptoms of ulcerative colitis in mice and exhibited comparable therapeutic effect to high-dose lactoferrin treatment. These findings indicate the promising potential of the silk sericin nanosphere system for colitis treatment.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

Poly-γ-Glutamic Acid Microgel-Encapsulated Probiotics with Gastric Acid Resistance and Smart Inflammatory Factor Targeted Delivery Performance to Ameliorate Colitis

Rui Wang et al.

Summary: This study proposes a novel hydrogel microcapsule strategy that can respond to nitric oxide stimulation and rapidly release probiotics to improve the mechanical barrier of the intestine and regulate the balance of intestinal flora, thus enhancing the treatment efficacy for inflammatory bowel disease.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Engineering, Biomedical

Oral nanotherapeutics based on Antheraea pernyi silk fibroin for synergistic treatment of ulcerative colitis

Ya Ma et al.

Summary: This study developed engineered Antheraea pernyi silk fibroin nanoparticles loaded with an anti-inflammatory drug, resveratrol, to target colonic epithelial cells and macrophages for effective ulcerative colitis (UC) treatment. The nanoparticles showed lysosomal escape capacity, pH and reactive oxygen species responsiveness, and targeted delivery to the cytoplasm for on-demand drug release. Oral treatment with these nanoparticles relieved UC symptoms by restoring damaged colonic epithelial barriers, reducing inflammation, and rebalancing intestinal microbiota.

BIOMATERIALS (2022)

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Article Pharmacology & Pharmacy

Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges

Li Shangyong et al.

Summary: Oral drug delivery systems have advantages of simplicity and minimal side effects, making them suitable for colon-targeted therapy. Chitosan/alginate nanoparticles (CANPs) show potential in the treatment of intestinal diseases due to their strong electrostatic interaction and intestinal mucosal adhesion.

DRUG DELIVERY (2022)

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Article Pharmacology & Pharmacy

Mesenchymal stromal cells encapsulated in licensing hydrogels exert delocalized systemic protection against ulcerative colitis via subcutaneous xenotransplantation

Ainhoa Gonzalez-Pujana et al.

Summary: The ability of mesenchymal stromal cells (MSCs) to release immunomodulatory factors makes them promising candidates for treating inflammatory bowel diseases (IBD). However, nude MSC administration has limitations such as loss of immunomodulatory phenotype and low persistence. In this study, a licensing hydrogel system was designed to overcome these limitations and achieve continuous delivery of bioactive factors. The results showed that encapsulated MSCs in the hydrogel limited the progression of IBD in mice.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Multidisciplinary Sciences

Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy

Dongxiao Zhang et al.

Summary: In this study, researchers have successfully developed an oral delivery system using Spirulina platensis as a microcarrier to protect the whole small intestine from radiation-induced injury during radiotherapy. The system accumulates the drug effectively and provides superior radioprotection compared to free drug and enteric capsules, preventing radiation-induced intestinal injury without affecting tumor regression. It also has benefits on gut microbiota homeostasis and long-term safety.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Biodegradable MoSe2-polyvinylpyrrolidone nanoparticles with multi-enzyme activity for ameliorating acute pancreatitis

Pei Xie et al.

Summary: This study reports a one-pot hydrothermal strategy for the facile preparation of MoSe2-polyvinylpyrrolidone (PVP) nanoparticles (NPs), which effectively mimicked various naturally occurring enzymes and exhibited cytoprotective effects. The therapeutic efficacy of MoSe2-PVP NPs was confirmed in an animal model of acute pancreatitis. The findings of this study can stimulate the development of other artificial nanoenzymes for antioxidant therapies.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Oral delivery of stem-cell-loaded hydrogel microcapsules restores gut inflammation and microbiota

Do-Wan Kim et al.

Summary: A strategy utilizing hydrogel microcapsules as an oral carrier enhances the survival and retention of mesenchymal stem cells in the gastrointestinal tract, effectively treating inflammatory bowel disease in a mouse model.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Engineering, Biomedical

Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

Hyo-Jin Yoon et al.

Summary: All-in-one treatments represent a paradigm shift in future medicine, allowing the treatment of inflammatory bowel disease (IBD) through endoscopic spray of injectable hydrogels. Peptide conjugation to the hydrogels enables guided monitoring of intestinal lesions and drug-free therapy by suppressing inflammatory signaling.

BIOACTIVE MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Multifunctional carboxymethyl chitosan/oxidized dextran/sodium alginate hydrogels as dressing for hemostasis and closure of infected wounds

Mengmeng Xie et al.

Summary: A multifunctional hydrogel has been developed that can rapidly stop bleeding and has antibacterial properties, promoting wound healing and repair. The hydrogel has good water retention capacity and mimics the three-dimensional structure of the natural extracellular matrix, making it promising for applications in hemostasis and wound healing.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Engineering, Environmental

Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis

Li Zhao et al.

Summary: The use of G4 PAMAM dendrimer to construct G4-ASA nanoparticles significantly increased the solubility of 5-ASA, resulting in the development of an injectable adhesive 5-ASA-loaded hydrogel. This new formulation demonstrated superior efficacy in alleviating symptoms of ulcerative colitis in experimental models.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease

Shangwen Zhang et al.

Summary: A pH-sensitive composite hyaluronic acid/gelatin hydrogel drug delivery system containing carboxymethyl chitosan microspheres loaded with CUR was fabricated for the treatment of IBD. In vitro studies showed good sustained release properties, with a drug release rate of 65% over 50 hours. In vivo pharmacokinetic experiments demonstrated that high levels of CUR were maintained in colon tissue for over 24 hours, exhibiting anti-inflammatory effects and inhibiting pro-inflammatory cytokines secretion. The formulation group of CUR@gels showed the best therapeutic effect on colitis in mice, indicating the potential of the composite gel delivery system for effective CUR delivery in colitis treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biophysics

Oxidation triggered formation of polydopamine-modified carboxymethyl cellulose hydrogel for anti-recurrence of tumor

Yu Zhang et al.

Summary: The research designed a hydrogel combining the abilities of PDT and PTT for tumor therapy, with good photothermal conversion, drug loading, and CT imaging capabilities.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Biochemistry & Molecular Biology

Influence of the Degree of Deacetylation of Chitosan and BMP-2 Concentration on Biocompatibility and Osteogenic Properties of BMP-2/PLA Granule-Loaded Chitosan/β-Glycerophosphate Hydrogels

Andrey Vyacheslavovich Vasilyev et al.

Summary: Chitosan hydrogel composite materials with optimized deacetylation degree of chitosan and the addition of highly porous polylactide granules achieved good mechanical properties and moldability. The composite materials impregnated with BMP-2 demonstrated excellent osteoinductive and osteoconductive properties in bone repair.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Pectin-Based Formulations for Controlled Release of an Ellagic Acid Salt with High Solubility Profile in Physiological Media

Marco Aldo Ortenzi et al.

Summary: This study focused on the low bioavailability of ellagic acid and developed a novel film by combining EA lysine salt with pectin to increase water solubility and control release at physiological targets. The results showed that the new film could achieve higher ellagic acid release in the small intestine environment and exhibited good prebiotic effects.

MOLECULES (2021)

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Article Gastroenterology & Hepatology

Histologic Outcomes With Vedolizumab Versus Adalimumab in Ulcerative Colitis: Results From An Efficacy and Safety Study of Vedolizumab Intravenous Compared to Adalimumab Subcutaneous in Participants With Ulcerative Colitis (VARSITY)

Laurent Peyrin-Biroulet et al.

Summary: The study found that Vedolizumab showed higher rates of histologic remission, minimal histologic disease activity, and combined histologic plus endoscopic outcomes compared to Adalimumab in the treatment of ulcerative colitis, regardless of whether the patients were anti-TNF-naive or had failed previous treatments.

GASTROENTEROLOGY (2021)

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Review Immunology

Systemic Immunoregulatory Consequences of Gut Commensal Translocation

Alex C. McPherson et al.

Summary: The gut microbiota plays a crucial role in systemic immunity during homeostasis and certain complex diseases, influencing immune responses through translocation. Bacterial translocation is emerging as a key player in immunomodulatory processes in non-gastrointestinal diseases.

TRENDS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

In vitro digestion of sodium alginate/pectin co-encapsulated Lactobacillus bulgaricus and its application in yogurt bilayer beads

Xinxin Hu et al.

Summary: This study successfully prepared SA/PE hydrogel microspheres using the extrusion method to encapsulate Lactobacillus bulgaricus, resulting in high encapsulation efficiency and viability. Double-layer beads containing probiotic microspheres and yogurt showed good physical and chemical properties, as well as commercial value.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Materials Science, Multidisciplinary

Preparation of cellulose-based hydrogel: a review

Sarah Husnaini Zainal et al.

Summary: Cellulose, the most abundant natural organic polymer on earth, has low solubility in water and most organic solvents. Specific solvent systems are required for cellulose applications. Hydrogel, as a 3D network structure, can retain a tremendous amount of water and highly depends on the crosslinking property.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2021)

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Article Materials Science, Biomaterials

An injectable anti-microbial and adhesive hydrogel for the effective noncompressible visceral hemostasis and wound repair

Zheng Chen et al.

Summary: The study developed a novel hemostatic hydrogel with a unique structure, capable of withstanding high blood pressure and exhibiting excellent hemostatic effects and biocompatibility, providing a new design approach for hemostasis and wound healing.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Polymer Science

Poly(glutamic acid): Production, composites, and medical applications of the next-generation biopolymer

Sung-Bin Park et al.

Summary: This review discusses the development of biopolymer-based functional composites for medical applications, with a focus on Poly(glutamic acid) (PGA) and its various composites. The study highlights the potential applications of PGA in vaccine adjuvants, cancer therapy, medical devices, and tissue regeneration, while also summarizing the challenges and emerging research in utilizing PGA in biomedical fields.

PROGRESS IN POLYMER SCIENCE (2021)

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Article Multidisciplinary Sciences

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Pengchao Zhao et al.

Summary: The authors have developed a bio-adhesive liquid coacervate coating that can act as a flowable drug carrier in the intestinal tract, mediating sustained release of drugs and enhancing therapeutic efficacy. This system shows significant stability, forming a physically adhesive coating on a large area of the intestinal tract for extended drug release.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Orally deliverable strategy based on microalgal biomass for intestinal disease treatment

Danni Zhong et al.

Summary: The innovative strategy of oral drug delivery using a formulation based on Spirulina platensis loaded with curcumin shows promise for treating intestinal diseases. The formulation not only improves drug bioavailability but also demonstrates excellent antitumor and anti-inflammatory efficacy.

SCIENCE ADVANCES (2021)

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Review Chemistry, Medicinal

Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine

Hengtong Zhang et al.

Summary: Alginates are natural polysaccharides extracted from brown marine algae and bacteria, known for their biocompatibility, biodegradability, non-toxicity, and gel formation properties. They can be processed into various forms like hydrogels, microspheres, fibers, and sponges, and have found wide applications in wound healing, tissue repair, and drug delivery in recent years.

MARINE DRUGS (2021)

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Article Biochemistry & Molecular Biology

Budesonide-Loaded Pectin/Polyacrylamide Hydrogel for Sustained Delivery: Fabrication, Characterization and In Vitro Release Kinetics

Manisha Pandey et al.

Summary: pH sensitive and enzymatically triggered hydrogel has been developed for colon-targeted delivery of budesonide in the treatment of ulcerative colitis, showing sustained drug release behavior and safety.

MOLECULES (2021)

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Article Engineering, Environmental

Thermo-sensitive hydrogel with mussel-inspired adhesion enhanced the non-fibrotic repair effect of EGF on colonic mucosa barrier of TNBS-induced ulcerative colitis rats through macrophage polarizing

Lifen Wang et al.

Summary: The thermo-sensitive hydrogel P-DA, inspired by mussel adhesion, showed good mechanical strength, delayed erosion, and stronger tissue adhesion, leading to improved mucosal absorption of therapeutic proteins. This system also enhanced the therapeutic effect of EGF on ulcerative colitis, with restoration of colonic morphology and function without fibrosis, possibly through polarization of macrophages from an inflammatory to anti-inflammatory phenotype.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Niranjan G. Kotla et al.

Summary: Hyaluronan, a naturally occurring biopolymer, has diverse biological effects and plays a crucial role in inflammation and cancer. This review discusses the sources, properties, and potential applications of hyaluronan in therapeutic systems and cancer targeting delivery.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Polymer Science

Assessing the pH responsive and mucoadhesive behavior of dexamethasone sodium phosphate loaded itaconic acid-grafted-poly(acrylamide)/carbopol semi-interpenetrating networks

Nyla Ajaz et al.

Summary: A dual responsive semi-IPN hydrogel was developed by free radical polymerization, which showed optimal drug release at pH 7.4. Toxicological and hemocompatibility tests confirmed the biocompatibility of the material.

JOURNAL OF POLYMER RESEARCH (2021)

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Article Materials Science, Biomaterials

Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats

Jie Sun et al.

Summary: A cysteamine-grafted gamma-polyglutamic acid hydrogel was synthesized to enhance the stability and therapeutic efficacy of rectally administered KPV for colitis. The KPV/SH-PGA hydrogel showed promising therapeutic effects in a rat model of ulcerative colitis.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Pharmacology & Pharmacy

Tailored Hydrogels as Delivery Platforms for Conditioned Medium from Mesenchymal Stem Cells in a Model of Acute Colitis in Mice

Juan Sendon-Lago et al.

Summary: This study found that using a hydrogel loaded with conditioned medium from human uterine cervical stem cells can effectively alleviate symptoms of colitis in mice.

PHARMACEUTICS (2021)

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Article Materials Science, Biomaterials

Thermosensitive polymer hydrogel as a physical shield on colonic mucosa for colitis treatment

Zhaoyuan Guo et al.

Summary: The study explores an injectable thermosensitive copolymer hydrogel as a topical formulation for the treatment of inflammatory bowel disease, demonstrating its feasibility in ulcerative colitis treatment by protecting ulcer sites and serving as a drug reservoir for sustained release.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Chemistry, Physical

Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

Yonghyun Lee et al.

NATURE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Amyloid-Polyphenol Hybrid Nanofilaments Mitigate Colitis and Regulate Gut Microbial Dysbiosis

Bing Hu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Polyphenol-Mediated Assembly of Proteins for Engineering Functional Materials

Yiyuan Han et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Chemistry, Medicinal

Advances in colon-targeted nano-drug delivery systems: challenges and solutions

Muhammad Naeem et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

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Article Biophysics

Effect of particle size on the cellular uptake and anti-inflammatory activity of oral nanotherapeutics

Xin Zhou et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Materials Science, Biomaterials

New tools to design smart thermosensitive hydrogels for protein rectal delivery in IBD

Lorena Garcia-del Rio et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Gastroenterology & Hepatology

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Sudabeh Alatab et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Review Education, Scientific Disciplines

Modified Pectins for Colon-Specific Drug Delivery

Aneesh Muvva et al.

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (2020)

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Review Chemistry, Multidisciplinary

Hypromellose - A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery

Eliska Maskova et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Physical

Mechanically Asymmetrical Triboelectric Nanogenerator for Self-Powered Monitoring of In Vivo Microscale Weak Movement

Bolang Cheng et al.

ADVANCED ENERGY MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Encapsulation of Lactobacillus rhamnosus in Hyaluronic Acid-Based Hydrogel for Pathogen-Targeted Delivery to Ameliorate Enteritis

Yao Xiao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Medicine, General & Internal

Development and Characterization of a New Endoscopic Drug-Eluting Platform With Proven Efficacy in Acute and Chronic Experimental Colitis

Ignacio Bon et al.

FRONTIERS IN MEDICINE (2020)

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Review Chemistry, Multidisciplinary

Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy

Eden Mariam Jacob et al.

NANOMATERIALS (2020)

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Article Pharmacology & Pharmacy

Anti-Inflammatory Activity of Chitosan and 5-Amino Salicylic Acid Combinations in Experimental Colitis

Henusha D. Jhundoo et al.

PHARMACEUTICS (2020)

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Review Immunology

The Role of Inflammation in Diabetic Retinopathy

John V. Forrester et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE(2)-mediated M2 macrophage polarization

Xiaocang Cao et al.

THERANOSTICS (2020)

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Article Biotechnology & Applied Microbiology

Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1-and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea

Biswaranjan Pradhan et al.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2019)

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Review Pharmacology & Pharmacy

Chitosan-based nanoparticles as drug delivery systems: a review on two decades of research

Sweet Naskar et al.

JOURNAL OF DRUG TARGETING (2019)

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Review Pharmacology & Pharmacy

Advances in orally-delivered pH-sensitive nanocarrier systems; an optimistic approach for the treatment of inflammatory bowel disease

Mahira Zeeshan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Multidisciplinary Sciences

Colonic epithelial cell diversity in health and inflammatory bowel disease

Kaushal Parikh et al.

NATURE (2019)

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Article Pharmacology & Pharmacy

Evaluation of a Methylcellulose and Hyaluronic Acid Hydrogel as a Vehicle for Rectal Delivery of Biologics

Andreea Aprodu et al.

PHARMACEUTICS (2019)

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Article Biochemistry & Molecular Biology

Efficacy of co-administration of modified apple polysaccharide and probiotics in guar gum-Eudragit S100 based mesalamine mini tablets: A novel approach in treating ulcerative colitis

Souvik Mohanta et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Medicine, General & Internal

Mucus and mucins in diseases of the intestinal and respiratory tracts

G. C. Hansson

JOURNAL OF INTERNAL MEDICINE (2019)

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Review Immunology

Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut

Ricard Garcia-Carbonell et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Novel biodegradable pH-sensitive hydrogels: An efficient controlled release system to manage ulcerative colitis

Mudassir Abbasi et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Engineering, Biomedical

IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair

Jose R. Garcia et al.

BIOMATERIALS (2019)

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Article Chemistry, Applied

Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery

Xueqing Zhang et al.

CARBOHYDRATE POLYMERS (2019)

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Article Materials Science, Biomaterials

Oral Administration of Hydrogel-Embedding Silk Sericin Alleviates Ulcerative Colitis through Wound Healing, Anti-Inflammation, and Anti-Oxidation

Ya Ma et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Review Medicine, General & Internal

Mechanisms of Disease: Inflammatory Bowel Diseases

Guilherme Piovezani Ramos et al.

MAYO CLINIC PROCEEDINGS (2019)

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Article Food Science & Technology

Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juicesn

Carla Mendes et al.

JOURNAL OF FUNCTIONAL FOODS (2019)

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Article Chemistry, Organic

Synthesis and engineering of sodium alginate/inulin core-shell nano-hydrogels for controlled-release oral delivery of 5-ASA

Fatemeh Bahadori et al.

ORGANIC COMMUNICATIONS (2019)

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Article Medicine, Research & Experimental

Chronic Model of Inflammatory Bowel Disease in IL-10-/- Transgenic Mice: Evaluation with Ultrasound Molecular Imaging

Huaijun Wang et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer

Bo Xiao et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Fully Bioabsorbable Natural-Materials-Based Triboelectric Nanogenerators

Wen Jiang et al.

ADVANCED MATERIALS (2018)

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Article Food Science & Technology

Stability of curcumin in oil-in-water emulsions: Impact of emulsifier type and concentration on chemical degradation

Mahesh Kharat et al.

FOOD RESEARCH INTERNATIONAL (2018)

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Review Polymer Science

Polymer engineering based on reversible covalent chemistry: A promising innovative pathway towards new materials and new functionalities

Ze Ping Zhang et al.

PROGRESS IN POLYMER SCIENCE (2018)

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Review Polymer Science

Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments-What Are the Capabilities?

Janine Griesser et al.

POLYMERS (2018)

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Article Engineering, Biomedical

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine

Wei Li et al.

BIOMATERIALS (2018)

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Article Chemistry, Multidisciplinary

TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis

Bo Xiao et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Immunology

Maintenance of intestinal homeostasis by mucosal barriers

Ryu Okumura et al.

INFLAMMATION AND REGENERATION (2018)

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Article Immunology

Ectopic expression of SIGIRR in the colon ameliorates colitis in mice by downregulating TLR4/NF-κB overactivation

Jinlin Liu et al.

IMMUNOLOGY LETTERS (2017)

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Article Chemistry, Multidisciplinary

Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis

Mark Martin Jensen et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Polymer Science

An Injectable Interpenetrating Polymer Network Hydrogel with Tunable Mechanical Properties and Self-Healing Abilities

Yanan Wang et al.

MACROMOLECULAR CHEMISTRY AND PHYSICS (2017)

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MOLECULAR THERAPY (2017)

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DIGESTIVE AND LIVER DISEASE (2017)

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Real-Time Fluorescence Tracking of Protoporphyrin Incorporated Thermosensitive Hydrogel and Its Drug Release in Vivo

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ACS APPLIED MATERIALS & INTERFACES (2016)

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Radiation Synthesis of Poly(Starch/Acrylic acid) pH Sensitive Hydrogel for Rutin Controlled Release

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

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FOOD RESEARCH INTERNATIONAL (2015)

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EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2015)

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Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

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Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: A review

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