Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 153, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2022.106329
Keywords
Viscosity; Tension; Temperature; Intracellular imaging probes
Categories
Funding
- National Heart, Lung, and Blood Institute
- Na-tional Institute of Biomedical Imaging and Bioengineering
- Air Force Office of Scientific Research
- [F31 HL154709]
- [R21 EB029677]
- [21RT0264-FA9550-21-1-0284]
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In this study, we review the progress made in imaging probes for three important physical parameters: viscosity, membrane tension, and temperature. These parameters play crucial roles in various cellular processes, and understanding their dynamics is crucial. We discuss the techniques used to measure these parameters at subcellular resolution and explore the future applications of recently developed techniques.
We review the progress made in imaging probes for three important physical parameters: viscosity, membrane tension, and temperature, all of which play important roles in many cellular processes. Recent evidences showed that cell migration speed can be modulated by extracellular fluid viscosity; membrane tension contributes to the regulation of cell motility, exo-/endo-cytosis, and cell spread area; and temperature affects neural activity and adipocyte differentiation. We discuss the techniques implementing imaging-based probes to measure viscosity, membrane tension, and temperature at subcellular resolution dynamically. The merits and shortcomings of each technique are examined, and the future applications of the recently developed techniques are also explored.
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