ADAR1 improved Treg cell function through the miR-21b/Foxp3 axis and inhibits the progression of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Article Environmental Sciences

miR-21-5p serves as a promoter in renal cell carcinoma progression through ARHGAP24 downregulation

Bin Meng et al.

Summary: This study reveals the stimulatory role of miR-21-5p in renal cell carcinoma and its contribution to the progression of the disease through the modulation of its downstream target gene ARHGAP24 expression.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Alterations in plasma miR-21, miR-590, miR-192 and miR-215 in idiopathic pulmonary fibrosis and their clinical importance

Hulya Dirol et al.

Summary: This study investigated the plasma levels of specific miRNAs in idiopathic pulmonary fibrosis (IPF) patients and found that miR-21 and miR-590 were overexpressed in IPF. Additionally, miR-192 and miR-215 were associated with the GAP score and the presence of honeycombing.

MOLECULAR BIOLOGY REPORTS (2022)

Add to Collection

Article Obstetrics & Gynecology

Downregulation of miR-21 is Involved in the Pathogenesis of Infection-Induced Preterm Birth by Targeting NF-κB

Lijun Duan et al.

Summary: Infection-induced preterm birth is a major factor contributing to increased maternal and fetal morbidity and mortality. This study found that miR-21 may be involved in the pathogenesis of infection-induced preterm birth by regulating NF-kappa B.

REPRODUCTIVE SCIENCES (2022)

Add to Collection

Article Surgery

MiR-21 in Lung Transplant Recipients With Chronic Lung Allograft Dysfunction

Naofumi Miyahara et al.

Summary: miR-21 expression was higher in restrictive allograft syndrome (RAS) than in bronchiolitis obliterans syndrome (BOS) specimens, with a significant increase in serum concentration over time in RAS patients. Vimentin, NICD, and p-SMAD 2/3 were positive in a higher proportion of BOS patients compared to RAS cases.

TRANSPLANT INTERNATIONAL (2022)

Add to Collection

Review Hematology

Acute Graft-versus-Host-Disease Other Than Typical Targets: Between Myths and Facts

Jacopo Mariotti et al.

Summary: Donor alloreactivity after transplantation can lead to graft-versus-host reaction (GVHR), affecting various organs beyond the well-recognized skin, liver, and gastrointestinal tract. Organs like the kidney, bone marrow, central nervous system, and lungs may also be involved, sparking debate on whether they are targets or collateral damage of the alloreactivity.

TRANSPLANTATION AND CELLULAR THERAPY (2021)

Add to Collection

Review Immunology

Treg cell therapy: How cell heterogeneity can make the difference

Giulio Giganti et al.

Summary: T regulatory cells play a crucial role in maintaining immune tolerance and controlling excessive immune responses. Pre-clinical studies have shown the therapeutic potential of these cells in immune-mediated diseases, but there are limitations in their clinical applications. Research has identified distinct subsets of Treg cells with different functions in immune response control, induction of peripheral tolerance, and maintenance of non-lymphoid tissue homeostasis, which can be exploited for novel therapeutic approaches.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Improved Therapeutic Approaches are Needed to Manage Graft-versus-Host Disease

Deborah S. Hooker et al.

Summary: Allogeneic haematopoietic stem cell transplantation offers a potentially curative therapy for hematopoietic diseases, but can lead to serious complications such as graft-versus-host disease (GvHD). European guidelines recommend calcineurin inhibitors and methotrexate for GvHD prophylaxis, but increasing disease severity can result in higher medical costs and non-relapse mortality rates.

CLINICAL DRUG INVESTIGATION (2021)

Add to Collection

Review Immunology

T-Cell Metabolism in Graft Versus Host Disease

Franziska Karl et al.

Summary: Allogeneic-hematopoietic stem cell transplantation is the only curative treatment for various hematological malignancies, but Graft-versus-Host-Disease often occurring with Graft-versus-Tumor effect poses a challenge for therapeutic efficacy. Immuno-metabolic interventions are being explored as a promising option to alleviate GvHD without compromising GvT activity. The interconnection between immunological and metabolic pathways is crucial in understanding and addressing the immuno-metabolic signature of GvHD-driving T-cells.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

T Cell Subsets in Graft Versus Host Disease and Graft Versus Tumor

Hua Jiang et al.

Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) is crucial for treating hematological malignancies, but acute and chronic graft-versus-host disease (aGVHD and cGVHD) are major complications. Understanding the roles of T cell subsets in GVHD pathogenesis is essential for identifying new therapeutic targets and improving outcomes.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

Jaclyn Quin et al.

Summary: Modified bases on cellular RNAs act as markers to distinguish endogenous RNA from foreign RNA, reducing innate immune responses. ADARs and other modified bases play important roles in innate immunity and cancer.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Add to Collection

Review Immunology

Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications

Yi Dong et al.

Summary: This review discusses emerging evidence of post-translational regulations on Foxp3 in Treg cells and their exciting therapeutic applications.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Hematology

Graft-versus-host disease: a disorder of tissue regeneration and repair

Ronjon Chakraverty et al.

Summary: In summary, regenerative failure at barrier surfaces and maladaptive repair leading to fibrosis are hallmarks of graft-versus-host disease (GVHD). While immunosuppressive treatment can control inflammation, impaired tissue homeostasis results in prolonged organ damage and impaired quality of life. Current interventions aim to address these critical failures in tissue regeneration and repair to improve therapeutic outcomes in GVHD.

BLOOD (2021)

Add to Collection

Review Biochemistry & Molecular Biology