4.7 Article

Construction and evaluation of GPC3-targeted immunotoxins as a novel therapeutic modality for hepatocellular carcinoma

Related references

Note: Only part of the references are listed.
Review Gastroenterology & Hepatology

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Maria Reig et al.

Summary: There have been significant advances in the treatment strategies for hepatocellular carcinoma since the last update in 2018. However, some interventions still lack sufficient data for clinical incorporation, and personalized clinical management requires consideration of multiple parameters.

JOURNAL OF HEPATOLOGY (2022)

Article Biotechnology & Applied Microbiology

A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC

Kaixin Du et al.

Summary: This study developed a novel bispecific antibody (BsAb) that targets both GPC3 and CD47, demonstrating strong antitumor activity against tumor cells expressing both antigens, with extended serum half-life and enhanced Fc-mediated effector functions in vitro. This approach outperformed monotherapies and a combination therapy in a xenograft HCC model, providing new insights for future antibody design in innovative immune therapies.

MOLECULAR THERAPY (2021)

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Food Science & Technology

DT389-YP7, a Recombinant Immunotoxin against Glypican-3 That Inhibits Hepatocellular Cancer Cells: An In Vitro Study

Hamid Hashemi Yeganeh et al.

Summary: A novel immunotoxin targeting an oncofetal marker on HCC cells was designed and investigated, showing high cytotoxic effects, especially on GPC3-positive cell lines.

TOXINS (2021)

Review Immunology

Recent development and optimization of pseudomonas aeruginosa exotoxin immunotoxins in cancer therapeutic applications

Tong Wu et al.

Summary: Recombinant immunotoxins are fusion proteins designed through genetic recombination, consisting of a peptide toxin and a targeting domain to recognize disease-specific receptors and induce cell death. Efforts are ongoing to address challenges such as immunogenicity and non-specific cytotoxicity, with recent strategies for structural optimization and mutagenesis showing promise in enhancing safety and efficacy. These immunotoxins are expected to play a crucial role in cancer therapy, with continuous advancements in design concepts and development prospects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Letter Oncology

IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin

Nengzhi Pang et al.

Summary: The study found that engineering human CAR-T cells to secrete human IL-7 and CCL19 (7x19) enhanced expansion and migration capabilities in vitro, and showed superior tumor suppression ability in experimental models compared to conventional CAR-T cells. In clinical trials, the incorporation of 7x19 into CAR-T cells led to significant tumor disappearance in patients with advanced HCC and PC, demonstrating the enhanced antitumor activity against human solid tumors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

A Rational Designed Novel Bispecific Antibody for the Treatment of GBM

Rui Sun et al.

Summary: The study demonstrated the remarkable antitumor activities of EGFRvIII-BsAb in inhibiting EGFRvIII highly expressed in lethal glioblastoma, indicating its potential as a promising therapeutic candidate for GBM treatment.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update

Bryan D. Fleming et al.

BIOMOLECULES (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

MRI-Based Radiomics Signature: A Potential Biomarker for Identifying Glypican 3-Positive Hepatocellular Carcinoma

Dongsheng Gu et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2020)

Article Medicine, Research & Experimental

32A9, a novel human antibody for designing an immunotoxin and CAR-T cells against glypican-3 in hepatocellular carcinoma

Xiaoyu Liu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Multidisciplinary Sciences

Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts

Vedud Purde et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biotechnology & Applied Microbiology

Combined Antitumor Effects of Sorafenib and GPC3-CAR T Cells in Mouse Models of Hepatocellular Carcinoma

Xiuqi Wu et al.

MOLECULAR THERAPY (2019)

Review Oncology

Glypican 3-Targeted Therapy in Hepatocellular Carcinoma

Takahiro Nishida et al.

CANCERS (2019)

Review Oncology

The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer

Aarti Kolluri et al.

FRONTIERS IN ONCOLOGY (2019)

Article Gastroenterology & Hepatology

Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma

Ying Fu et al.

HEPATOLOGY (2019)

Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Pharmacology & Pharmacy

Moxetumomab Pasudotox: First Global Approval

Sohita Dhillon

DRUGS (2018)

Article Biotechnology & Applied Microbiology

Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial

Vidyalakshmi Chandramohan et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2017)

Article Cell Biology

An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors

Takahiro Ishiguro et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Review Chemistry, Multidisciplinary

New knowledge of the mechanisms of sorafenib resistance in liver cancer

Yan-jing Zhu et al.

ACTA PHARMACOLOGICA SINICA (2017)

Review Cell Biology

The future of antiviral immunotoxins

Katja Spiess et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2016)

Review Oncology

Hepatocellular carcinoma: From diagnosis to treatment

Miral Sadaria Grandhi et al.

SURGICAL ONCOLOGY-OXFORD (2016)

Review Oncology

GPC-3 in hepatocellular carcinoma: current perspectives

Yongle Wu et al.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2016)

Article Pathology

Glypican 3 overexpression in primary and metastatic Wilms tumors

Maria Tretiakova et al.

VIRCHOWS ARCHIV (2015)

Review Pathology

Discovery and Diagnostic Value of a Novel Oncofetal Protein: Glypican 3

Sean K. Wang et al.

ADVANCES IN ANATOMIC PATHOLOGY (2014)

Article Biotechnology & Applied Microbiology

Development and Scale-Up of a Commercial Fed Batch Refolding Process for an Anti-CD22 Two Chain Immunotoxin

Thomas Linke et al.

BIOTECHNOLOGY PROGRESS (2014)

Review Biochemistry & Molecular Biology

The role of glypicans in Hedgehog signaling

Jorge Filmus et al.

MATRIX BIOLOGY (2014)

Article Multidisciplinary Sciences

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

Mingqian Feng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Oncology

Abstract 2426: Anti-Glypican3 antibody for treatment of human liver cancer

Takahiro Ishiguro et al.

CANCER RESEARCH (2011)

Article Oncology

Anti-Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer

Takahiro Ishiguro et al.

CANCER RESEARCH (2008)

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Oncology

Drug penetration in solid tumours

Andrew I. Minchinton et al.

NATURE REVIEWS CANCER (2006)

Review Biochemistry & Molecular Biology

Inteins as enzymes

H Paulus

BIOORGANIC CHEMISTRY (2001)

Review Biotechnology & Applied Microbiology

Recent progress in biomolecular engineering

DDY Ryu et al.

BIOTECHNOLOGY PROGRESS (2000)