Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 113, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2022.109466
Keywords
IBD; NOD2; Microbiota; Therapeutic target; Immune response; miRNA
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Funding
- Project of Zhenjiang key research and development plan (social development) [SH2021066]
- 169 Project Scientific Research Project of Zhenjiang City, Teacher Specialty Leading Person Senior Research Project in Higher Vocational College of Jiangsu Province [2022GRGDYX059]
- Clinical medical research center of Gynecology and Traditional Chinese Medicine of Zhenjiang [SS202204KFC01]
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This review discusses the role of nucleotide-binding oligomerization domaincontaining protein 2 (NOD2) in intestinal immune response and microbiota modulation in inflammatory bowel disease (IBD), and explores its clinical potential as a therapeutic target for IBD.
As an intracellular pattern recognition receptor (PPR), the nucleotide-binding oligomerization domaincontaining protein 2 (NOD2) triggers a cascade of immune responses. Previous studies of NOD2 regarding inflammatory bowel disease (IBD) mainly focused on the relevance of NOD2 mutations and loss within the disease onset and progression. With increasing research, more studies are exploring other functional roles and clinical applications of NOD2. In this review, we discuss the role of NOD2 in intestinal immune response and microbiota modulation in IBD and explore its clinical potential as a therapeutic target for IBD.
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