Rivastigmine ameliorates gentamicin experimentally induced acute renal toxicity

The current experiment aimed to identify the possible protective role of rivastigmine (RIVA) in gentamicin (GNT)-induced acute kidney injury (AKI) in rats. RIVA was administered in the presence and absence of GNT. Kidney function markers and serum and renal GNT concentrations were measured. Renal oxidative stress pa-rameters as well as inflammatory and apoptotic biomarkers were evaluated. Renal histopathological assessment and nuclear factor kappa-B (NF-kappa B) immunohistochemical study were performed. GNT administration increased serum creatinine, urea, and cystatin C concentrations. RIVA ameliorated these changes via mitigating GNT-induced increases of renal oxidative stress, inflammation, and apoptotic parameters. RIVA showed a prompt improvement in the histopathological renal damage and a decrease in NF-kappa B immunoexpression. In conclusion, RIVA protective effects against GNT-induced AKI are mediated by decreasing GNT concentration in renal tissue and other effects like antioxidant and antiapoptotic effects possibly through its cholinergic anti-inflammatory action.

Automated summary

The current study aimed to investigate the protective effects of rivastigmine in gentamicin-induced acute kidney injury. The results demonstrated that rivastigmine could ameliorate renal dysfunction by reducing oxidative stress, inflammation, and apoptotic reactions induced by gentamicin, and by decreasing the concentration of gentamicin in renal tissue.