4.7 Article

Innate immune tolerance against adolescent intermittent alcohol exposure-induced behavioral abnormalities in adult mice

Related references

Note: Only part of the references are listed.
Article Immunology

Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice

Fu Li et al.

Summary: Pre-stimulation of the innate immune system by MPL can prevent chronic stress-induced anxiety-like behaviors and neuroinflammatory responses in the brain in mice.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Immunology

IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation

Ana Amorim et al.

Summary: Using a mouse model of neuroinflammation, this study reveals that IFN gamma is essential for the acquisition of a mature inflammatory phagocyte phenotype in Ly6C(hi) monocytes, while GM-CSF is required for phagocytosis, IL-1 beta production, and ROS release. The findings suggest that the proinflammatory cytokine environment guides the developmental trajectories of MTPT in the inflamed CNS and highlights GM-CSF as a crucial target for suppressing monocyte progenies during neuroinflammation.

NATURE IMMUNOLOGY (2022)

Article Clinical Neurology

Role of mTOR-regulated autophagy in spine pruning defects and memory impairments induced by binge-like ethanol treatment in adolescent mice

Maria Pascual et al.

Summary: The study investigates the effects of binge alcohol drinking during adolescence on synaptic plasticity and cognitive function in mice, as well as the potential of mTOR inhibitor rapamycin to restore these effects.

BRAIN PATHOLOGY (2021)

Article Immunology

Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice

Yue Gu et al.

Summary: The study found that injecting the innate immune enhancer LPS can prevent behavioral abnormalities induced by chronic social defeat stress in mice, with the optimal effect observed at specific doses and time points. Additionally, innate immune stimulation can alter neuroinflammatory responses in the brain, and inhibiting central innate immune response can eliminate the tolerance-inducing effect of LPS preconditioning.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Psychiatry

Adversity in childhood/adolescence and premorbid tobacco, alcohol, and cannabis use among first-episode psychosis patients

Stephanie Langlois et al.

Summary: This study found meaningful associations between childhood/adolescent adversity and premorbid substance use in first-episode psychosis patients, with Violence and Environmental Adversity having the greatest impact on substance use. Interpersonal Abuse and Neglect and Lack of Connectedness showed less significant associations with substance use. The study suggests the importance of assessing childhood/adolescent adversity, particularly factors related to violence exposure, in first-episode psychosis and clinical high-risk treatment settings.

EARLY INTERVENTION IN PSYCHIATRY (2021)

Article Immunology

Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice

Shuoshuo Li et al.

Summary: The study revealed the critical role of microglial activation in PTSD, with an increase in microglia number and ratio post foot-shock exposure. Genetic/pharmacological depletion of microglia or minocycline treatment before exposure alleviated anxiety and contextual fear associated with PTSD.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Neurosciences

Effects of adolescent intermittent ethanol on hippocampal expression of glutamate homeostasis and astrocyte-neuronal tethering proteins in male and female rats

Kati L. Healey et al.

Summary: Adolescent alcohol exposure has lasting effects on astrocyte function and interactions, with specific effects observed in different sexes and brain regions.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Article Biochemistry & Molecular Biology

Tissue-specific features of microglial innate immune responses

R. Timmerman et al.

Summary: Microglia, as tissue-resident macrophages of the brain, are increasingly considered as cellular targets for therapeutical intervention due to their impact on innate immune responses. Their responses are characterized by slower kinetics, a more persistent nature, and differential usage of downstream enzymes and accessory receptors. Factors like aging, previous exposure to inflammatory stimuli, and differences in the microenvironment can modulate their innate immune responses.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Sex difference in the vulnerability to hippocampus plasticity impairment after binge-like ethanol exposure in adolescent rat: Is estrogen the key?

Kevin Rabiant et al.

Summary: This study found that endogenous estrogen levels may explain why adolescent females are more vulnerable to ethanol-induced plasticity impairments compared to males. The research results suggest that E2 levels play a role in the gender differences in the effects of ethanol on hippocampal plasticity.

ADDICTION BIOLOGY (2021)

Article Neurosciences

Alcohol drinking during early adolescence activates microglial cells and increases frontolimbic Interleukin-1 beta and Toll-like receptor 4 gene expression, with heightened sensitivity in male rats compared to females

Andrea Silva-Gotay et al.

Summary: Adolescent voluntary alcohol intake can lead to a pro-inflammatory state in the brain, with males being more affected; binge drinking alcohol activates microglia in the brain, triggering inflammatory responses.

NEUROPHARMACOLOGY (2021)

Article Immunology

Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes

Songji Li et al.

Summary: Recent research has found that genetic variants of Cntn1 are linked to major depressive disorders. Overexpression of Cntn1 in the hippocampus triggers anxiety- and depression-like phenotypes, microglia activation, and reduced immature neurons in the hippocampus. These findings suggest that Cntn1 plays a role in regulating anxiety and depression through functional actions in the hippocampus.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Neurosciences

Adolescent intermittent ethanol (AIE) produces sex specific alterations in adult neuroimmune gene expression and ethanol sensitivity that are independent of ethanol metabolism

Andrew S. Vore et al.

Summary: The present studies demonstrate that adolescent intermittent ethanol exposure has long-lasting effects on adult ethanol sensitivity and neuroimmune gene expression, with significant differences between sexes.

NEUROPHARMACOLOGY (2021)

Article Neurosciences

A prophylactic effect of macrophage-colony stimulating factor on chronic stress-induced depression-like behaviors in mice

Jianlin Ji et al.

Summary: The study demonstrated that M-CSF preconditioning can alleviate stress-induced depression-like behaviors by modulating neuroinflammatory responses.

NEUROPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA2Activity in Immature Cultured Cortical Preparations

J. L. Santerre-Anderson et al.

NEUROCHEMICAL RESEARCH (2020)

Article Neurosciences

Neurobehavioral effects of alcohol in overcrowded male adolescent rats

Fatma M. Sabry et al.

NEUROSCIENCE LETTERS (2020)

Article Biochemistry & Molecular Biology

Altered brain cortical maturation is found in adolescents with a family history of alcoholism

Bharath Holla et al.

ADDICTION BIOLOGY (2019)

Review Pharmacology & Pharmacy

Developmental trajectories of brain maturation and behavior: Relevance to major mental illnesses

Sedona Lockhart et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2018)

Review Neurosciences

Effects of adolescent alcohol consumption on the brain and behaviour

Linda P. Spear

NATURE REVIEWS NEUROSCIENCE (2018)

Article Clinical Neurology

Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway

Feng-Guo Liu et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2017)

Article Clinical Neurology

Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences

Eric S. Wohleb et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)

Article Multidisciplinary Sciences

Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice

Stefan O. Reber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Pharmacology & Pharmacy

Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior

Fulton T. Crews et al.

PHARMACOLOGICAL REVIEWS (2016)

Article Substance Abuse

Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Adolescent Versus Adult Mice

Cynthia J. M. Kane et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)

Article Substance Abuse

Characterizing Alcohol Use Disorders and Suicidal Ideation in Young Women

Arpana Agrawal et al.

JOURNAL OF STUDIES ON ALCOHOL AND DRUGS (2013)

Article Biochemistry & Molecular Biology

Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition

Tao Pang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

Article Endocrinology & Metabolism

Long-lasting protection in brain trauma by endotoxin preconditioning

Luca Longhi et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)