Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 113, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2022.109412
Keywords
Primary membranous nephropathy; Cytokines; Inflammation; Autoimmune
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Funding
- Capital's Funds for Health Improvement and Research [2020-2-2234]
- National Natural Science Foundation of China [82174314]
- Beijing Natural Science Foundation [7214289]
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This article explores the role of cytokines in primary membranous nephropathy (PMN), and clarifies whether inflammation is involved in its pathological process. It also suggests certain cytokines as potential biomarkers or therapeutic targets.
There have been extensive studies on the immunological mechanism of primary membranous nephropathy (PMN). Autoantibodies, being the end product of humoral auto-immunity, matter much in diagnosis, therapy and prediction. Although PMN has been thought of as oligoinflammatory glomerulopathy, autoimmune diseases usually involve inflammation and it may be long-lasting. Cytokines are key mediators and effector molecules of inflammatory and humoral immune responses. Their function and network are helpful to understand the immune mechanism of PMN, but there is a lack of systematic summary. Accordingly, this review explores the advance of cytokines in PMN, and clarifies whether inflammation involves in the pathological process of PMN, based on which certain cytokines are proposed as potential biomarkers or therapeutic targets, and the importance of updating existing therapy regimens is highlighted.
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