Journal
INORGANICA CHIMICA ACTA
Volume 545, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2022.121286
Keywords
Phosphine oxides; Pyridine; CuII complexes; O-chelating ligands; Cytotoxicity; X-ray diffraction; N
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Water-soluble copper(II) complexes based on novel phosphorylpyridines, diethyl(pyridin-2-yl) phosphine oxide (3) and diisopropyl(pyridin-2-yl)phosphine oxide (4), were synthesized and their molecular and crystal structures were determined by X-ray analysis. The cytotoxicity of the ligands and complexes against M-HeLa and HuTu80 cancer cell lines as well as Chang liver normal cell lines was evaluated.
Water-soluble copper(II) complexes based on novel phosphorylpyridines, namely, diethyl(pyridin-2-yl) phosphine oxide (3), diisopropyl(pyridin-2-yl)phosphine oxide (4) were obtained. The molecular and crystal structures of complexes were established by X-ray analysis. The cytotoxicity against M-HeLa and HuTu80 cancer cell lines and Chang liver normal cell lines was examined for all obtained ligands and complexes.
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