4.7 Article

Modification of 4-Fold and B-Pores in Bacterioferritin from Mycobacterium tuberculosis Reveals Their Role in Fe2+Entry and Oxidoreductase Activity

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Controlled Uptake of an Iridium Complex inside Engineered apo-Ferritin Nanocages: Study of Structure and Catalysis**

Mohd Taher et al.

Summary: The study shows that mutations at the core of the ferritin nanocage can impact the uptake of IrCp*, with mutation of Arg52 by His leading to a significant increase in uptake. Additionally, the ferritin variants were found to exhibit high activity and enantioselectivity in catalyzing transfer hydrogenation reactions.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Article Biochemistry & Molecular Biology

Pseudomonas aeruginosa Bacterioferritin Is Assembled from FtnA and BfrB Subunits with the Relative Proportions Dependent on the Environmental Oxygen Availability

Huili Yao et al.

Summary: Bacteria cells have two types of iron storage proteins, and P. aeruginosa utilizes a single heterooligomeric Bfr assembled from FtnA and BfrB subunits for iron storage.

BIOMOLECULES (2022)

Review Biochemistry & Molecular Biology

Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology

Abhinav Mohanty et al.

Summary: Bionanotechnology applies nanomaterials to solve biological problems, with ferritin protein nanocages emerging as a potential solution due to their self-assembly, thermal stability, and natural iron scavenging ability.

ACS BIO & MED CHEM AU (2022)

Article Chemistry, Inorganic & Nuclear

Alteration of Coaxial Heme Ligands Reveals the Role of Heme in Bacterioferritin from Mycobacterium tuberculosis

Abhinav Mohanty et al.

Summary: Iron uptake and utilization are critical for host and pathogens, with ferritins playing a key role in managing iron ions and solubility. Bacterial ferritin in Mycobacterium tuberculosis binds heme through conserved methionine residues, potentially enhancing protein stability and iron mobilization.

INORGANIC CHEMISTRY (2021)

Article Chemistry, Medicinal

Small Molecule Inhibitors of the Bacterioferritin (BfrB)-Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells

Anabel Soldano et al.

Summary: Research has shown that blocking the BfrB-Bfd complex in P. aeruginosa triggers the accumulation of iron and cytosolic iron deficiency, significantly impairing biofilm development. Small molecules developed to bind BfrB at the Bfd binding site can inhibit the mobilization of iron and have bacteriostatic and bactericidal effects on planktonic cells and cells embedded in mature biofilms.

ACS INFECTIOUS DISEASES (2021)

Article Biochemistry & Molecular Biology

Flavin-mediated reductive iron mobilization from frog M and Mycobacterial ferritins: impact of their size, charge and reactivities with NADH/O2

Prashanth Kumar Koochana et al.

Summary: The study demonstrates the reductive iron mobilization from ferritins using three flavin analogues, with riboflavin (RF) being the most effective in releasing iron. The generation of O-2(center dot-) during the reaction plays a significant role in the iron release process.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Kinetics of Ferritin Self-Assembly by Laser Light Scattering: Impact of Subunit Concentration, pH, and Ionic Strength

Abhinav Mohanty et al.

Summary: Ferritins are self-assembled, hollow spherical nanocage proteins composed of 24 subunits, with inherent reversibility. Factors such as subunit concentration, ionic strength, and medium pH were found to influence the kinetics of ferritin self-assembly, which can be regulated to enhance drug/nanomaterial loading/unloading.

BIOMACROMOLECULES (2021)

Article Chemistry, Inorganic & Nuclear

Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe2+ Uptake from Mycoplasma

Wenming Wang et al.

Summary: The 1.9 A resolution crystal structure of Mycoplasma Penetrans ferritin reveals that its ferroxidase center is positioned on the inner surface of ferritin rather than buried within each subunit's four-helix. This unique ferritin also shows lower iron oxidation activity and allows Fe2+ to enter via B-channels instead of the usual 3- or 4-fold channels, suggesting a novel iron oxidation mechanism.

INORGANIC CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Bacterial iron detoxification at the molecular level

Justin M. Bradley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity

Achala N. D. Punchi Hewage et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Chemistry, Multidisciplinary

Iron Acquisition in Mycobacterium tuberculosis

Alex Chao et al.

CHEMICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Surface charge dependent separation of modified and hybrid ferritin in native PAGE: Impact of lysine 104

Biswamaitree Subhadarshanee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2017)

Article Biochemistry & Molecular Biology

Iron Oxidation and Core Formation in Recombinant Heteropolymeric Human Ferritins

Matthew Mehlenbacher et al.

BIOCHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Diversity of Fe2+ entry and oxidation in ferritins

Justin M. Bradley et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2017)

Review Chemistry, Multidisciplinary

Solving Biology's Iron Chemistry Problem with Ferritin Protein Nanocages

Elizabeth C. Theil et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Electrostatic and Structural Bases of Fe2+ Translocation through Ferritin Channels

Balasubramanian Chandramouli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Ferritins: furnishing proteins with iron

Justin M. Bradley et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Modulating the permeability of ferritin channels

C. Bernacchioni et al.

RSC ADVANCES (2016)

Review Biochemistry & Molecular Biology

Use of the confined spaces of apo-ferritin and virus capsids as nanoreactors for catalytic reactions

Basudev Maity et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage

Stephanie Pfaffen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Fe2+ substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization

Rabindra K. Behera et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2015)

Article Neurosciences

Neuroferritinopathy: From ferritin structure modification to pathogenetic mechanism

Sonia Levi et al.

NEUROBIOLOGY OF DISEASE (2015)

Review Chemistry, Multidisciplinary

Unity in the Biochemistry of the Iron-Storage Proteins Ferritin and Bacterioferritin

Kourosh Honarmand Ebrahimi et al.

CHEMICAL REVIEWS (2015)

Article Biochemistry & Molecular Biology

The B-type Channel Is a Major Route for Iron Entry into the Ferroxidase Center and Central Cavity of Bacterioferritin

Steve G. Wong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

A Histidine Aspartate Ionic Lock Gates the Iron Passage in Miniferritins from Mycobacterium smegmatis

Sunanda Margrett Williams et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Biochemistry & Molecular Biology

Mechanisms of iron mineralization in ferritins: one size does not fit all

Justin M. Bradley et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

IdeR is required for iron homeostasis and virulence in Mycobacterium tuberculosis

Ruchi Pandey et al.

MOLECULAR MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Moving Fe2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates

Rabindra K. Behera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Thermodynamic Effects of the Alteration of the Axial Ligand on the Unfolding of Thermostable Cytochrome c

Rabindra Kumar Behera et al.

BIOCHEMISTRY (2013)

Review Chemistry, Inorganic & Nuclear

Ferritins for chemistry and for life

Elizabeth C. Theil et al.

COORDINATION CHEMISTRY REVIEWS (2013)

Article Chemistry, Medicinal

Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target

Cedric P. Owens et al.

FUTURE MEDICINAL CHEMISTRY (2013)

Article Chemistry, Inorganic & Nuclear

Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease

Elizabeth C. Theil

INORGANIC CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Ferritin and ferrihydrite nanoparticles as iron sources for Pseudomonas aeruginosa

Carolyn Dehner et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2013)

Article Chemistry, Multidisciplinary

The structural characterization of bacterioferritin, BfrA, from Mycobacterium tuberculosis

Lisa M. McMath et al.

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES (2013)

Article Biochemistry & Molecular Biology

Fe-haem bound to Escherichia coli bacterioferritin accelerates iron core formation by an electron transfer mechanism

Steve G. Wong et al.

BIOCHEMICAL JOURNAL (2012)

Article Chemistry, Inorganic & Nuclear

Ferritin Ion Channel Disorder Inhibits Fe(II)/O2 Reactivity at Distant Sites

Takehiko Tosha et al.

INORGANIC CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry

Elizabeth C. Theil

CURRENT OPINION IN CHEMICAL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Self-Assembly in the Ferritin Nano-Cage Protein Superfamily

Yu Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Biochemistry & Molecular Biology

A New Role for Heme, Facilitating Release of Iron from the Bacterioferritin Iron Biomineral

Samina Yasmin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Moving Iron through Ferritin Protein Nanocages Depends on Residues throughout Each Four α-Helix Bundle Subunit

Suranjana Haldar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

X-ray structures of ferritins and related proteins

Robert R. Crichton et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)

Review Biochemistry & Molecular Biology

The iron redox and hydrolysis chemistry of the ferritins

Fadi Bou-Abdallah

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)

Review Biochemistry & Molecular Biology

The ferritin superfamily: Supramolecular templates for materials synthesis

Masaki Uchida et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)

Article Biochemistry & Molecular Biology

Thermodynamic basis of the thermostability of CYP175A1 from Thermus thermophilus

Rabindra Kumar Behera et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2010)

Article Chemistry, Multidisciplinary

Moving Metal Ions through Ferritin-Protein Nanocages from Three-Fold Pores to Catalytic Sites

Takehiko Tosha et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Review Biochemistry & Molecular Biology

Ferritins: A family of molecules for iron storage, antioxidation and more

Paolo Arosio et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Article Chemistry, Multidisciplinary

Structural Basis for Iron Mineralization by Bacterioferritin

Allister Crow et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Multidisciplinary Sciences

Detergent binding explains anomalous SDS-PAGE migration of membrane proteins

Arianna Rath et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemical Research Methods

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of bacterioferritin A from Mycobacterium tuberculosis

Vibha Gupta et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2008)

Article Multidisciplinary Sciences

The ferritin Fe2 site at the diiron catalytic center controls the reaction with O2 in the rapid mineralization pathway

Takehiko Tosha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites

Louise Toussaint et al.

JOURNAL OF MOLECULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

μ-1,2-1-Peroxo diferric complex formation in horse spleen ferritin.: A mixed H/L-subunit heteropolymer

GH Zhao et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

PRALINE: a multiple sequence alignment toolbox that integrates homology-extended and secondary structure information

VA Simossis et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Chemistry, Multidisciplinary

Origin of the unusual kinetics of iron deposition in human H-chain ferritin

F Bou-Abdallah et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Review Chemistry, Multidisciplinary

Ferritins: Dynamic management of biological iron and oxygen chemistry

XF Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2005)

Article Multidisciplinary Sciences

Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients

J Timm et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

μ-1,2-peroxobridged di-iron(III) dimer formation in human H-chain ferritin

F Bou-Abdallah et al.

BIOCHEMICAL JOURNAL (2002)