Neuroblastoma Stage 4S (MS): Identification of Risk Factors and Treatment Decisions

Article Pediatrics

Management and Outcomes of Children with Stage 4S (MS) Neuroblastoma: A Single-Center Experience from a Resource-Challenged Nation

Sachit Anand et al.

Summary: This study demonstrates the clinical profile, management options, and outcomes of children with stage 4S neuroblastoma (NB 4S) in a resource-challenged nation. The study highlights age, respiratory distress, and chemotherapy nonresponsiveness as independent predictors of a poor outcome.

INDIAN JOURNAL OF PEDIATRICS (2023)

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Review Pediatrics

Stage 4S Neuroblastoma: What Are the Outcomes? A Systematic Review of Published Studies

Arimatias Raitio et al.

Summary: The prognosis of stage 4S/MS neuroblastoma is traditionally considered excellent, but patients with MYCN amplification and 1p/11q deletion have a dismal outcome. Conservative management or surgical excision of the primary tumor provides the best prognosis for these infants.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY (2021)

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Article Oncology

Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group

Meredith S. Irwin et al.

Summary: A revised neuroblastoma risk classifier incorporating INRGSS and SCAs has been validated, which may impact clinical trial eligibility and treatment assignment.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Pediatrics

Resection of primary tumor in stage 4S neuroblastoma: a second study by the Italian Neuroblastoma Group

Stefano Avanzini et al.

Summary: The study aimed to clarify the role of primary tumor resection in stage 4S neuroblastoma by investigating a cohort of 172 infants diagnosed between 1994 and 2013. The results showed that upfront surgery led to significantly better 5-year progression-free and overall survival rates.

PEDIATRIC SURGERY INTERNATIONAL (2021)

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Article Oncology