Related references
Note: Only part of the references are listed.Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function
Lydia Dyck et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2022)
Immune Infiltration of CD8+T Cells in Patients With Diabetic Pancreatic Cancer Reduces the Malignancy of Cancer Tissues: An In Silico Study
Zheng Ye et al.
FRONTIERS IN ENDOCRINOLOGY (2022)
Metabolic Regulation of CD8+ T Cells: From Mechanism to Therapy
Ying Zheng et al.
ANTIOXIDANTS & REDOX SIGNALING (2022)
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Mathias Wenes et al.
CELL METABOLISM (2022)
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Qinghua Wu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)
The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8+T Cells
Trupti Vardam-Kaur et al.
JOURNAL OF IMMUNOLOGY (2022)
Adult mouse fibroblasts retain organ-specific transcriptomic identity
Elvira Forte et al.
ELIFE (2022)
Tumor-Derived Lactate Creates a Favorable Niche for Tumor via Supplying Energy Source for Tumor and Modulating the Tumor Microenvironment
Mengyao Jin et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells
Ilaria Elia et al.
CELL METABOLISM (2022)
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
Zheng Gong et al.
IMMUNITY (2022)
Tissue-resident memory CD8(+) T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments
John T. Crowl et al.
NATURE IMMUNOLOGY (2022)
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Silvia Gaggero et al.
Science Immunology (2022)
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites
Jordan W. Conway et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
Nicole E. Scharping et al.
NATURE IMMUNOLOGY (2021)
Metabolism of Amino Acids in Cancer
Zhen Wei et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
Giusy Di Conza et al.
NATURE IMMUNOLOGY (2021)
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer
Deanna N. Edwards et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity
Yao He et al.
CELL METABOLISM (2021)
Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+T cells
Ilkka Liikanen et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Cross-tissue organization of the fibroblast lineage
Matthew B. Buechler et al.
NATURE (2021)
Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells
Nadia Bannoud et al.
FRONTIERS IN IMMUNOLOGY (2021)
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
Shihao Xu et al.
IMMUNITY (2021)
Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma
Yang Cheng et al.
IMMUNITY (2021)
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
Justina X. Caushi et al.
NATURE (2021)
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity
Susan N. Christo et al.
NATURE IMMUNOLOGY (2021)
Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes
Loreto Parga-Vidal et al.
SCIENCE IMMUNOLOGY (2021)
Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program
Farah Hasan et al.
JCI INSIGHT (2021)
Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer
Violet Y. Tu et al.
ANTIBODIES (2021)
Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways
Won Jin Ho et al.
GENOME BIOLOGY (2021)
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer
Shuaishuai Teng et al.
CELL RESEARCH (2020)
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Haiping Wang et al.
NATURE IMMUNOLOGY (2020)
Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T cells
Sarah L. Hayward et al.
NATURE IMMUNOLOGY (2020)
Fatty Acid Oxidation Controls CD8+ Tissue-Resident Memory T-cell Survival in Gastric Adenocarcinoma
Run Lin et al.
CANCER IMMUNOLOGY RESEARCH (2020)
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy
J. Justin Milner et al.
IMMUNITY (2020)
The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy
Aaron R. Lim et al.
ELIFE (2020)
The Effects of Obesity on Anti-Cancer Immunity and Cancer Immunotherapy
Matthew J. Woodall et al.
CANCERS (2020)
Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes
H. Frizzell et al.
SCIENCE IMMUNOLOGY (2020)
Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β
Henrique Borges da Silva et al.
IMMUNITY (2020)
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells
Teresa Manzo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2020)
Structural cells are key regulators of organ-specific immune responses
Thomas Krausgruber et al.
NATURE (2020)
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
Lars Muhl et al.
NATURE COMMUNICATIONS (2020)
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
Yingjie Bian et al.
NATURE (2020)
Disturbed mitochondrial dynamics in CD8+TILs reinforce T cell exhaustion
Yi-Ru Yu et al.
NATURE IMMUNOLOGY (2020)
The Gut Microbiome Is Associated with Clinical Response to Anti-PD-1/PD-L1 Immunotherapy in Gastrointestinal Cancer
Zhi Peng et al.
CANCER IMMUNOLOGY RESEARCH (2020)
Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways
Yi-Na Liu et al.
FRONTIERS IN IMMUNOLOGY (2020)
Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer
Justin T. Gibson et al.
FRONTIERS IN IMMUNOLOGY (2020)
Resident Memory T Cells and Their Effect on Cancer
Daniel J. Craig et al.
VACCINES (2020)
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Alison E. Ringel et al.
CELL (2020)
Lactate Limits T Cell Proliferation via the NAD(H) Redox State
William J. Quinn et al.
CELL REPORTS (2020)
PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment
Catherine T. Le et al.
FRONTIERS IN IMMUNOLOGY (2020)
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
Takeshi Tanoue et al.
NATURE (2019)
Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Xingzhe Ma et al.
CELL METABOLISM (2019)
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
Mark R. Sullivan et al.
ELIFE (2019)
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells
Annabel Bachem et al.
IMMUNITY (2019)
T Cell Activation Depends on Extracellular Alanine
Noga Ron-Harel et al.
CELL REPORTS (2019)
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Robert D. Leone et al.
SCIENCE (2019)
Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis
Tomonobu Kado et al.
SCIENTIFIC REPORTS (2019)
VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancers
Chang Gon Kim et al.
SCIENCE IMMUNOLOGY (2019)
Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin
Simone L. Park et al.
NATURE (2019)
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells
Lelisa F. Gemta et al.
SCIENCE IMMUNOLOGY (2019)
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
V. Gopalakrishnan et al.
SCIENCE (2018)
CD103+ Tumor-Resident CD8+ T Cells Are Associated with Improved Survival in Immunotherapy-Naive Melanoma Patients and Expand Significantly During Anti-PD-1 Treatment
Jarem Edwards et al.
CLINICAL CANCER RESEARCH (2018)
Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
Bertram Bengsch et al.
IMMUNITY (2018)
Pulmonary antigen encounter regulates the establishment of tissue-resident CD8 memory T cells in the lung airways and parenchyma
Sean R. McMaster et al.
MUCOSAL IMMUNOLOGY (2018)
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
Daniele V. F. Tauriello et al.
NATURE (2018)
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
Peter Savas et al.
NATURE MEDICINE (2018)
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
Henrique Borges da Silva et al.
NATURE (2018)
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Sanjeev Mariathasan et al.
NATURE (2018)
Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity
Natalija Van Braeckel-Budimir et al.
CELL REPORTS (2018)
Resident memory T cells, critical components in tumor immunology
Fathia Mami-Chouaib et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
Karolina Pilipow et al.
JCI INSIGHT (2018)
CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin
Stanley Cheuk et al.
IMMUNITY (2017)
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
Youdong Pan et al.
NATURE (2017)
Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours
J. Justin Milner et al.
NATURE (2017)
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
Michel Enamorado et al.
NATURE COMMUNICATIONS (2017)
Induction of resident memory T cells enhances the efficacy of cancer vaccine
Mevyn Nizard et al.
NATURE COMMUNICATIONS (2017)
Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites
Brahma V. Kumar et al.
CELL REPORTS (2017)
Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity
Bram Slutter et al.
SCIENCE IMMUNOLOGY (2017)
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
Ying Zhang et al.
CANCER CELL (2017)
Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy
Haiping Wang et al.
TRENDS IN CANCER (2017)
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
Anusha-Preethi Ganesan et al.
NATURE IMMUNOLOGY (2017)
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma
Peter J. Siska et al.
JCI INSIGHT (2017)
Resident memory T cells in the skin mediate durable immunity to melanoma
Brian T. Malik et al.
SCIENCE IMMUNOLOGY (2017)
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
David Clever et al.
CELL (2016)
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Roger Geiger et al.
CELL (2016)
Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley et al.
CELL (2016)
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Shawn M. Davidson et al.
CELL METABOLISM (2016)
CD103 and Intratumoral Immune Response in Breast Cancer
Zhi-Qiang Wang et al.
CLINICAL CANCER RESEARCH (2016)
Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection
Daniel Fernandez-Ruiz et al.
IMMUNITY (2016)
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
Chandra Sekhar Boddupalli et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Cristovao M. Sousa et al.
NATURE (2016)
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Jared R. Mayers et al.
SCIENCE (2016)
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Laura K. Mackay et al.
SCIENCE (2016)
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
Edoardo Gaude et al.
NATURE COMMUNICATIONS (2016)
Hypoxia and antitumor CD8+ T cells: An incompatible alliance?
Romain Vuillefroy de Silly et al.
ONCOIMMUNOLOGY (2016)
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ping-Chih Ho et al.
CELL (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
Fanny Dupuy et al.
CELL METABOLISM (2015)
CD8+ CD103+ Tumor-Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients
Faycal Djenidi et al.
JOURNAL OF IMMUNOLOGY (2015)
Gastrointestinal Fibroblasts Have Specialized, Diverse Transcriptional Phenotypes: A Comprehensive Gene Expression Analysis of Human Fibroblasts
Youichi Higuchi et al.
PLOS ONE (2015)
PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian Cancer
John R. Webb et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells
Cara N. Skon et al.
NATURE IMMUNOLOGY (2013)
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Laura K. Mackay et al.
NATURE IMMUNOLOGY (2013)
Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
Christine Feig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
Rosula Garcia-Navas et al.
AUTOPHAGY (2012)
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
Mariia O. Yuneva et al.
CELL METABOLISM (2012)
Metabolic checkpoints in activated T cells
Ruoning Wang et al.
NATURE IMMUNOLOGY (2012)
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
Wei Tan et al.
NATURE (2011)
Obesity and postprandial lipemia in adolescents: Risk factors for cardiovascular disease
Viviane Sahade et al.
Endocrinologia y Nutricion (2011)
Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine
Minu K. Srivastava et al.
CANCER RESEARCH (2010)
CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4
Alexander J. Bankovich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor β
Shuang Wei et al.
CANCER RESEARCH (2008)
Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype
M Buchholz et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2005)
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
GF Debes et al.
NATURE IMMUNOLOGY (2005)
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
Y Makino et al.
JOURNAL OF IMMUNOLOGY (2003)
Regulation of T cell receptor CD3 chain expression by L-arginine
PC Rodriguez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Ligand specificity and conformational stability of human fatty acid-binding proteins
AW Zimmerman et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)