4.7 Article

PPh3O as an Activating Reagent for One-Pot Stereoselective Syntheses of Di- and Polybrominated Esters from Simple Aldehydes

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 7, Pages 2730-2736

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b02618

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Funding

  1. NSFC [21172097, 21202070, 21302075, 21372105]
  2. International S&T Cooperation Program of China [2013DFR70580]
  3. National Natural Science Foundation from Gansu Province of China [1204WCGA015]
  4. 111 program from MOE of P. R. China

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An efficient one-pot method for the syntheses of di- and polybrominated esters from readily available aldehydes is reported. The direct use of the in situ generated byproduct PPh3O in the following reactions greatly improves the efficiency of the cascade. Also, the substrate scope of the reaction is proved to be broad.

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