Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 10, Pages 4048-4057Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00341
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2014R1A1A1003650]
- Kwangwoon University
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A highly efficient and mild Cu-catalyzed conjugate addition reaction of aromatic amines and aromatic aza-heterocycles to alpha,beta-unsaturated olefins is described. The transformation is promoted by 3-7 mol % of a Cu complex generated in situ from a mixture of inexpensive CuCl, a readily available phosphine or imidazolium salt, and KOt-Bu at ambient temperature. A wide range of beta-amino sulfone, beta-amino nitrile, and beta-amino carbonyl compounds is efficiently and selectively synthesized in high yields (62-99%).
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