Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 20, Pages 9878-9885Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02020
Keywords
-
Categories
Funding
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2016R1A4A1011189, 2015R1A2A1A15053033]
Ask authors/readers for more resources
The rhodium(III)-catalyzed direct C-H functionalization of various indolines with 1,4,2-dioxazol-5-ones as new amidating agents is described. This transformation provides efficient preparation of C7-amidated indolines known to display potent anticancer activity. The synthetic compounds were evaluated for in vitro anticancer activity against human prostate adenocarcinoma cells (LNCaP), human endometrial adenocarcinoma cells (Ishikawa), and human ovarian carcinoma cells (SKOV3). Compound 4f was found to be highly cytotoxic, with activity competitive with that of anticancer agent doxorubicin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available