Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 24, Pages 12416-12425Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02577
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Funding
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [2016R1A4A1011189, 2016R1C1B2010456, 2015R1A2A1A15053033]
- National Research Foundation of Korea [2016R1C1B2010456] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The weakly coordinating ketone group directed C-H functionalizations of chromones, 1,4-naphthoquinones, and xanthones with various maleimides under rhodium(III) catalysis are described. These protocols efficiently provide a range of succinimide-containing chromones, naphthoquinones, and xanthones with excellent site selectivity and functional group compatibility. All synthetic compounds were screened for in vitro anticancer activity against human breast adenocarcinoma cell lines (MCF-7). In particular, compounds 7aa and 7ca with a naphthoquinone scaffold were found to be highly cytotoxic, with an activity competitive with anticancer agent doxorubicin.
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