4.7 Article

MeOTf- and TBD-Mediated Carbonylation of ortho-Arylanilines with CO2 Leading to Phenanthridinones

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 15, Pages 6672-6676

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b01318

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Funding

  1. National Natural Science Foundation of China [21472106, 21272132]
  2. National Key Basic Research Program of China (973 program) [2012CB933402]

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Carbonylation of o-arylanilines utilizing CO2 as a carbonyl source for the synthesis of important phenanthridinones with a free (NH)-lactam motif has been described under metal-free condition. A range of o-arylanilines were transformed to the corresponding phenanthridinones in high yields.

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