Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 22, Pages 10975-10986Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02013
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Funding
- National Science Foundation [NSF21272101, NSF21472073, NSF21472074, NSF21302076]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1138, IRT15R28]
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A strategy for the synthesis of 6,9-dihydropyrido[1,2-a]indoles through a cascade iodocyclization of 4-(3-methyl-1H-indol-1-yl)-1,1-diphenylbut-2-yri-1-ol derivatives is presented. This reaction was conducted under very mild conditions and in a short time. The reactions are metal-free, are environmentally friendly and give up to 94% yield. Moreover, the obtained halides allow functional group diversification by palladium-catalyzed coupling reactions, which could act as potential intermediates for the synthesis of valuable compounds.
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