Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 24, Pages 12514-12519Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02404
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Funding
- Russian Scientific Fund [14-50-00069]
- Russian Science Foundation [14-50-00069] Funding Source: Russian Science Foundation
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N-Arylation of 2-imidazolines with arylboronic acids promoted by copper(II) acetate in DMSO provides an attractive alternative to the earlier reported transition metal-catalyzed approaches employing (hetero)aryl halides as it taps into the vast reagent space of commercially available boronic acids and proceeds at ambient temperature. Many of the resulting compounds are distinctly lead-like, thus positioning the method developed well within the toolbox of lead-oriented synthesis.
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