Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 5, Pages 2053-2061Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b02914
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Funding
- National Natural Science Foundation of China [21420102003]
- Fundamental Research Funds for the Central Universities [2015ZY001]
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A convenient and reliable method for the direct construction of isoquinolines is described. A series of isoquinoline derivatives were synthesized, with high chemo- and regioselectivities, via the copper-catalyzed cascade reaction of 2-haloaryloxime acetates with beta-diketones, beta-keto esters, and beta-keto nitriles. This tandem annulation process features inexpensive catalysts, no need for additional ligands, and excellent functional group tolerance, which makes it have potential synthetic applications. Furthermore, this strategy could also be used to enter functionalized indolo[1,2-a]quinazolines by using indoles as the counterpart of the 2-haloaryloxime acetates.
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