Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 7, Pages 2958-2965Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00245
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Funding
- CAPES
- CNPq
- FINEP-MCT
- FINATEC
- FAPDF
- DPP-UnB
- Brazilian Research Council CNPq [306968/2013-4]
- Brazilian Research Council FAP-DF [0193.001.062/2015]
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This paper describes the synthesis, structure, photophysical properties, and bioimaging application of a novel 2,1,3-benzothiadiazole (BTD)-based rationally designed fluorophore. The capability of undergoing efficient stabilizing processes from the excited state allowed the novel BTD derivative to be used as a stable probe for bioimaging applications. No notable photobleaching effect or degradation could be observed during the experimental time period. Before the synthesis, the molecular architecture of the novel BTD derivative was evaluated by means of DFT calculations to validate the chosen design. Single-crystal X-ray analysis revealed the nearly flat characteristics of the structure in a syn conformation. The fluorophore was successfully tested as a live-cell-imaging probe and efficiently stained MCF-7 breast cancer cell lineages.
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