4.7 Article

Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 17, Pages 7760-7770

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b01426

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Funding

  1. University of Rennes 1
  2. Centre National de la Recherche Scientifique (CNRS)

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One-pot formation of arylacetic acid esters, thioesters, and amides via Rh(II)-catalyzed arylation of a Meldrurn's acid-derived diazo reagent with electron-rich arenes is described. The methodology was used to efficiently synthesize an anticancer compound.

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