Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 24, Pages 12525-12531Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02408
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A method for the coupling of aryl bromides with potassium alkyl trifluoroborates, via nickel/photoredox dual catalysis, has been developed for use in continuous flow. This operationally simple protocol is able to form Csp(3)-Csp(2) bonds with significantly reduced reaction times and a broader substrate scope than when conducted in batch. The utility of this method for rapid analog synthesis has been demonstrated by the synthesis of a small library of alkyl-substituted quinazolines.
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