Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 9, Pages 3901-3910Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b00264
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Funding
- NSFC [21421004, 21190033, 21372072, 21561162003]
- NCET [NCET-13-0798]
- Basic Research Program of the Shanghai Committee of Sci. Tech. [13M1400802]
- Programme of Introducing Talents of Discipline to Universities [B16017]
- Program for Eastern Scholar Distinguished Professor
- Fundamental Research Funds for the Central Universities
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A Rh(III)-catalyzed coupling/cyclization cascade reaction is described, which involves arylimidates and diazo compounds and proceeds via intermolecular C-C bond formation and subsequent intramolecular C-N bond formation. Mechanistic investigation revealed that the reaction is a two-step process: the initial Rh(III)-catalyzed coupling/cyclization proceeds very fast and the following dehydration is rather slow. The reaction provides a direct approach to isoquinolines and isoquinolin-3-ols without any oxidants.
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