Introduction of Quinolines and Isoquinolines onto Nonactivated α-C-H Bond of Tertiary Amides through a Radical Pathway

Treatment of quinolines and isoquinolines with benzoyl peroxide in tertiary amides, such as N,N-dimethylacetamide, N,N-dimethylpropionamide, and N-acetylpyrrolidine, etc., under irradiation with a Hg lamp in the temperature range of 35 degrees C to 40 degrees C gave C-C-bonded quinolines and isoquinolines bearing amide groups with high regioselectivity in good to moderate yields, respectively, under transition-metal-free conditions.