Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 24, Pages 12318-12331Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02264
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- University of Glasgow
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A highly functionalized intermediate in the synthesis of Taxol has been synthesized, which features the tricyclic core and the required oxygen substituents at C1, C2, C7, C10, and C13. The key step, a ring-closing dienyne metathesis (RCDEYM) reaction, has been thoroughly optimized to favor the tricyclic product over the undesired bicyclic product resulting from diene metathesis.
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