Benign and Malignant Skin Lesions: Dielectric Characterization, Modelling and Analysis in Frequency Band 1 to 14 GHz

Objective: This paper aims to characterize Non-Melanoma malignancies and their corresponding benign conditions in ex-vivo/in-vivo tissue environments to study the feasibility of microwave techniques for skin cancer detection. Methods: The dielectric dataset is developed across the frequency band 1 to 14 GHz using Keysight slim-form and RG405 probe characterization systems. The acquired reflection data captured by the systems is converted to dielectric values using the Open-Water-Short and Open-Water-Liquid calibration methods, respectively. Furthermore, the impact of anaesthesia application during skin excision procedure on ex-vivo dielectric data is investigated. Results: The observations suggest that the dielectric properties (DPs) of excised skin lesions may not accurately represent actual tissue properties as they vary significantly (Dielectric Constant Contrast = 30.7%, Loss Factor Contrast = 66.6%) compared to pre-excision conditions. In-vivo dielectric data analysis indicates that when compared to healthy skin, malignant Basal Cell Carcinoma presents increased DPs (dielectric constant & loss factor) of (24.8 & 38.6%), respectively. On the other hand, for malignant Squamous Cell Carcinoma and pre-malignant Actinic Keratosis, the measured results show decreased DPs (dielectric constant & loss factor) accordingly by (19.4 & 18.2%) and (19.2 & 27.9%). The corresponding benign lesions have less than 13% dielectric contrast compared to healthy skin across the tested band. Conclusion: The significant contrasts between in-vivo healthy and cancerous skin DPs strongly suggest the viability of the microwave band for skin cancer detection. Significance: The research finding of this study would be critical in developing a portable electromagnetic system for skin cancer detection.

Automated summary

The aim of this study is to characterize non-melanoma malignancies and their corresponding benign conditions in ex-vivo/in-vivo tissue environments, and to investigate the feasibility of microwave techniques for skin cancer detection. The results suggest that there are significant differences in the dielectric properties between cancerous and healthy skin in the in-vivo environment, indicating the potential viability of the microwave band for skin cancer detection.