Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 81, Issue 20, Pages 9886-9894Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02061
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- JGC-Scholarship Foundation
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Miuraenamides A and D, cyclodepsipeptides with antimicrobial and antitumor activity, were synthesized. The synthesis of an unsaturated hydroxycarboxylic acid moiety, starting from a chiral epoxide, was achieved by Suzuki-Miyaura coupling as a key step. As a result, the overall yield for miuraenamide A over the longest linear sequence is 3.2%, while the yield of the previously reported procedure is 1.9%. In addition, the cell growth-inhibitory activity and anti-Phytophthora activity of the synthesized compounds were evaluated.
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