4.7 Review

Recent Advances in Hypertension: Epigenetic Mechanism Involved in Development of Salt-Sensitive Hypertension

Related references

Note: Only part of the references are listed.
Article Peripheral Vascular Disease

Association Between DNA Methylation and Blood Pressure: A 5-Year Longitudinal Twin Study

Xuanming Hong et al.

Summary: This study identified CpG sites associated with systolic and diastolic blood pressure and examined the temporal relationship between DNA methylation and blood pressure. The findings suggest the significance of DNA methylation in the development of hypertension.

HYPERTENSION (2023)

Review Peripheral Vascular Disease

Sensitization of Hypertension: The Impact of Earlier Life Challenges: Excellence Award for Hypertension Research 2021

Baojian Xue et al.

Summary: Hypertension affects over 1 billion individuals worldwide, and the cause is largely unknown. Increased sympathetic nervous system activity is common in hypertensive patients, but the root cause is still unclear. Recent research has found that the neural network controlling sympathetic drive becomes more reactive after exposure to mild challenges, leading to a sensitized hypertensive response. Plasticity in the neural network and the involvement of various factors are necessary for the induction and maintenance of this state. This review discusses the induction and expression of this sensitized hypertensive response in adult animals and the offspring of mothers with prenatal obesity/overnutrition or maternal gestational hypertension, as well as interventions to reverse the effects of stressor-induced sensitization.

HYPERTENSION (2023)

Article Peripheral Vascular Disease

Unique Associations of DNA Methylation Regions With 24-Hour Blood Pressure Phenotypes in Blacks

Michelle L. Roberts et al.

Summary: This study identified DNA methylation regions that are significantly associated with 24-hour blood pressure phenotypes, which may serve as important markers for blood pressure regulation. The newly developed methylation sequencing method has potential for clinical testing and large-scale population screenings.

HYPERTENSION (2022)

Article Peripheral Vascular Disease

Famine and Trajectories of Body Mass Index, Waist Circumference, and Blood Pressure in Two Generations: Results From the CHNS From 1993-2015

Jie Li et al.

Summary: Early-life exposure to the Chinese famine of 1959 to 1962 is associated with increased BMI, WC, and BP in two consecutive generations, with sex and age disparities.

HYPERTENSION (2022)

Article Cardiac & Cardiovascular Systems

Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension

Nian Cao et al.

Summary: This study found that adverse prenatal exposure induces transgenerational hypertension through an epigenetic-regulated mechanism, and identified potentially preventive and therapeutic strategies for hypertension.

CIRCULATION (2022)

Review Peripheral Vascular Disease

Gut-Immune-Kidney Axis: Influence of Dietary Protein in Salt-Sensitive Hypertension

David L. Mattson et al.

Summary: Salt-sensitive hypertension in patients with high blood pressure is associated with higher morbidity, mortality, and renal damage compared to those with normal blood pressure or salt-resistant hypertension. Dietary components other than salt play a role in modulating hypertension, and immunity and inflammation are key factors that amplify the development of salt-sensitive hypertension.

HYPERTENSION (2022)

Review Peripheral Vascular Disease

Developmental and Early Life Origins of Cardiometabolic Risk Factors Novel Findings and Implications

Empar Lurbe et al.

Summary: This review critically considers the association between birth weight, growth trajectories, and cardiometabolic disease, highlighting the importance of early life interventions in reducing disease burden and improving public health outcomes.

HYPERTENSION (2021)

Review Urology & Nephrology

Kidney and epigenetic mechanisms of salt-sensitive hypertension

Wakako Kawarazaki et al.

Summary: This review discusses the impact of adverse environmental factors such as prenatal malnutrition, obesity, and aging on salt-sensitive hypertension, as well as the underlying mechanisms. Kidney mechanisms and aberrant DNA methylation of certain genes play crucial roles in the development of this condition.

NATURE REVIEWS NEPHROLOGY (2021)

Article Peripheral Vascular Disease

Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans

Srividya Kidambi et al.

Summary: This study found that dietary sodium restriction significantly affects DNA methylation in T cells and arterioles, with specific regions of methylation associated with changes in blood pressure. The results contribute to a better understanding of the interactions between dietary sodium and cellular processes, potentially leading to novel therapeutic targets.

HYPERTENSION (2021)

Article Peripheral Vascular Disease

Epigenetic Modifications in T Cells The Role of DNA Methylation in Salt-Sensitive Hypertension

John Henry Dasinger et al.

HYPERTENSION (2020)

Article Medicine, Research & Experimental

Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency

Wakako Kawarazaki et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Endocrinology & Metabolism

Effects of maternal and paternal exercise on offspring metabolism

Joji Kusuyama et al.

NATURE METABOLISM (2020)

Review Biochemistry & Molecular Biology

DNA Methylation and Histone Modification in Hypertension

Shaunrick Stoll et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Peripheral Vascular Disease

Role of DNA De Novo (De)Methylation in the Kidney in Salt-Induced Hypertension

Pengyuan Liu et al.

HYPERTENSION (2018)

Review Peripheral Vascular Disease

Epigenetic Mechanisms and Hypertension

Mingyu Liang

HYPERTENSION (2018)

Article Medicine, Research & Experimental

Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal programmed hypertension

Fumiko Kawakami-Mori et al.

JCI INSIGHT (2018)

Article Genetics & Heredity

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

Melissa A. Richard et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Review Cell Biology

Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations

Vicencia Micheline Sales et al.

CELL METABOLISM (2017)

Review Biochemistry & Molecular Biology

Unravelling the complex mechanisms of transgenerational epigenetic inheritance

Georgina E. T. Blake et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2016)

Article Peripheral Vascular Disease

Developmental Programming of Hypertension: Physiological Mechanisms

John Henry Dasinger et al.

HYPERTENSION (2016)

Article Peripheral Vascular Disease

Salt Sensitivity of Blood Pressure A Scientific Statement From the American Heart Association

Fernando Elijovich et al.

HYPERTENSION (2016)

Article Endocrinology & Metabolism

Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring

Nicole O. McPherson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2015)

Article Biochemistry & Molecular Biology

Soluble αKlotho as a candidate for the biomarker of aging

Daisuke Koyama et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Neurosciences

Dnmt3a in Sim1 Neurons Is Necessary for Normal Energy Homeostasis

Daisuke Kohno et al.

JOURNAL OF NEUROSCIENCE (2014)

Review Urology & Nephrology

Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease

Miki Nagase et al.

NATURE REVIEWS NEPHROLOGY (2013)

Review Cell Biology

The complex world of WNT receptor signalling

Christof Niehrs

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Medicine, Research & Experimental

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway

Shigeru Shibata et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Biochemistry & Molecular Biology

Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension

ShengYu Mu et al.

NATURE MEDICINE (2011)

Article Peripheral Vascular Disease

Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic Syndrome

Toshiro Fujita

HYPERTENSION (2010)

Article Biochemistry & Molecular Biology

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

Christophe Guilluy et al.

NATURE MEDICINE (2010)

Article Biochemistry & Molecular Biology

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease

Shigeru Shibata et al.

NATURE MEDICINE (2008)

Article Multidisciplinary Sciences

Augmented Wnt signaling in a mammalian model of accelerated aging

Hongjun Liu et al.

SCIENCE (2007)

Article Multidisciplinary Sciences

Suppression of aging in mice by the hormone Klotho

H Kurosu et al.

SCIENCE (2005)