Optimal 25-OH-Vitamin D Level in Children Derived From Biochemical Parameters

The aim of the study was to evaluate the bone-optimal pediatric levels of 25-hydroxy-vitamin D (25OHD) by testing the level at which 25OHD optimally effects calcium, phosphorus, and parathyroid hormone levels in a large population-based dataset. This was an observational retrospective big-data study. We analyzed 49 935 25OHD tests from children sampled in Clalit Health Services, Jerusalem district between 2009 and 2019. Associated data were available in the following number of samples: corrected calcium; 18 869, phosphorus: 1241, and PTH: 449. We tested correlations between each parameter and 25OHD, adjusting phosphorus levels by age using a phosphorus index . Pearson's and Spearman's correlation coefficients were calculated to determine the strength of the correlation between 25OHD and each parameter. There was a significant correlation between 25OHD levels and both PTH and calcium but not for the phosphorus index. The level at which increase in 25OHD continued to cause significant alteration was: for PTH up to 100 nmol/l (40 ng/ml), for corrected calcium it increased beyond 100 nmol/l. Increasing levels of 25OHD levels up to at least 100 nmol/l are associated with improvement in parameters known to be associated with increased bone mineralization. Therefore, one should aim for a 25OHD level of 100 nmo/l.

Automated summary

The aim of this study was to determine the optimal pediatric levels of 25-hydroxy-vitamin D (25OHD) for bone health. The study analyzed a large dataset of 49,935 25OHD tests from children sampled between 2009 and 2019. Significant correlations were found between 25OHD levels and parathyroid hormone (PTH) and calcium, indicating that increasing 25OHD levels up to at least 100 nmol/l can improve bone mineralization.