Journal
HOMEOPATHY
Volume 112, Issue 3, Pages 160-169Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0042-1755364
Keywords
breast cancer; homeopathy; arsenic trioxide; Arsenicum album; apoptosis; cell cycle; migration; ROS generation; hallmarks of cancer
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The study evaluated the anti-cancer potential of arsenic trioxide in hormone-dependent breast cancer. The results showed that arsenic trioxide could inhibit cell proliferation, induce apoptosis, and reduce cell migration in breast cancer cells. Further research is needed to elucidate the mechanism of action of arsenic trioxide in vivo.
Background Arsenic trioxide (As2O3 ) has been in therapeutic use since the 18th century for various types of cancers including skin and breast; however, it gained popularity following FDA approval for its use against acute promyelocytic leukemia. This present work was designed to evaluate the anti-cancer potential of a homeopathic potency of arsenic trioxide (Arsenicum album 6C) in hormone-dependent breast cancer. Methods Breast cancer cells (MCF7) were treated with Arsenicum album ( Ars 6C) to evaluate its anti-proliferative and apoptotic potential. We examined the effect of Ars 6C on the cell cycle, wound healing, reactive oxygen species (ROS) generation, and modulation of expression of key genes which are aberrant in cancer. Results Treating breast cancer cells with Ars 6C halted the cell cycle at the sub-G0 and G2/M phases, which could be attributed to DNA damage induced by the generation of ROS. Apoptotic induction was associated with upregulation of Bax expression, with concurrent downregulation of the Bcl-2 gene. Ars 6C was also seen to reverse epithelial to mesenchymal transition and reduce the migration of breast cancer cells.Conclusion The findings suggest that Ars has significant anti-proliferative and apoptotic potential against breast cancer cells. Further studies are required to elucidate the mechanism by which Ars exerts its effect in the in vivo setting.
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