Gut microbiota-derived metabolites in atrial fibrillation: risk markers or modifiable risk factors?

Article Cardiac & Cardiovascular Systems

Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation

Marco Luciani et al.

Summary: This study investigated the role of trimethylamine-N-oxide (TMAO) in predicting adverse events in patients with atrial fibrillation. The results showed that high levels of TMAO are associated with increased risk of cardiovascular mortality and cerebral infarction.

HEART (2023)

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Review Cardiac & Cardiovascular Systems

Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications

Monika Gawalko et al.

Summary: Recent studies suggest that imbalances in gut microbiota composition may contribute to atrial fibrillation (AF), a condition where the heart beats irregularly. The gut microbiota is a complex ecosystem of trillions of microorganisms that can be influenced by factors such as diet and drugs, in addition to individual characteristics. Research explores the potential bidirectional relationship between AF and gut microbiota, examining how the microbiota's metabolites could affect AF development. Additionally, investigations into modifying gut microbiota through pharmacological and dietary interventions are discussed as potential methods to prevent AF progression.

CARDIOVASCULAR RESEARCH (2022)

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Review Nutrition & Dietetics

Gut Microbiota-Derived Metabolites and Cardiovascular Disease Risk: A Systematic Review of Prospective Cohort Studies

Raul Sanchez-Gimenez et al.

Summary: Gut microbiota-derived metabolites, including trimethylamine N-oxide, bile acids, and branched-chain amino acids, are associated with adverse cardiovascular events and cardiovascular disease.

NUTRIENTS (2022)

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Article Engineering, Biomedical

A wearable electrochemical biosensor for the monitoring of metabolites and nutrients

Minqiang Wang et al.

Summary: A wearable electrochemical biosensor has been developed to continuously detect trace levels of multiple metabolites and nutrients in sweat during physical exercise and at rest, providing real-time monitoring and assessment of health risks and nutritional status.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Cardiac & Cardiovascular Systems

Trimethylamine-N-oxide (TMAO) is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation

M Luciani et al.

EUROPEAN HEART JOURNAL (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Does gut microbiota affect atrial rhythm? Causalities and speculations

Dominik Linz et al.

Summary: Dietary intake can alter gut microbiota composition, with dysbiosis linked to risk factors for AF; although the exact mechanisms through which dysbiosis contributes to AF remain unclear, further research may open up new possibilities in AF management.

EUROPEAN HEART JOURNAL (2021)

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Article Biotechnology & Applied Microbiology