Remote electrical neuromodulation for migraine prevention: A double-blind, randomized, placebo-controlled clinical trial

Article Anesthesiology

Combining Guided Intervention of Education and Relaxation (GIER) with Remote Electrical Neuromodulation (REN) in the Acute Treatment of Migraine

Dawn C. Buse et al.

Summary: Combining the GIER behavioral intervention with REN treatment can improve therapeutic efficacy beyond that of REN alone, in terms of both pain relief and improvement of function.

PAIN MEDICINE (2022)

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Article Nursing

Migraine in Adult Primary Care

Cory Wilbanks

Summary: Migraine is a common primary headache disorder that has a negative impact on patients' lives and can potentially lead to disability. There are multiple treatment options available, and the management process is complex.

JNP- THE JOURNAL FOR NURSE PRACTITIONERS (2022)

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Article Anesthesiology

Comparison of Remote Electrical Neuromodulation and Standard-Care Medications for Acute Treatment of Migraine in Adolescents: A Post Hoc Analysis

Andrew D. Hershey et al.

Summary: Remote electrical neuromodulation (REN) is a novel nonpharmacological treatment that shows higher efficacy than standard-care medications for the acute treatment of migraine in adolescents. REN group achieved better pain relief and consistency compared to the medication group.

PAIN MEDICINE (2022)

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Article Medicine, General & Internal

Treatment Patterns for Calcitonin Gene-Related Peptide Monoclonal Antibodies Including Galcanezumab versus Conventional Preventive Treatments for Migraine: A Retrospective US Claims Study

Oralee J. Varnado et al.

Summary: Real-world treatment patterns for CGRP mAb, specifically galcanezumab, showed higher adherence and persistence compared to standard-of-care (SOC) migraine preventive treatments.

PATIENT PREFERENCE AND ADHERENCE (2022)

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Article Clinical Neurology

Effectiveness comparison of remote electrical neuromodulation and standard-care medications for acute treatment of chronic migraine: a post-hoc analysis

Brian Grosberg et al.

Summary: The current study compared the effectiveness of remote electrical neuromodulation (REN) to that of standard-care medications for acute treatments of migraine and found no statistical differences in the effectiveness outcomes. This suggests that REN may provide an effective non-pharmacological alternative for individuals impacted by chronic migraine.

PAIN MANAGEMENT (2022)

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Article Clinical Neurology

Real-World Analysis of Remote Electrical Neuromodulation (REN) for the Acute Treatment of Migraine

Jessica Ailani et al.

Summary: The analysis of real-world clinical data demonstrates that REN is an effective, stable, and safe treatment option for acute migraine, both as a standalone treatment and as an adjunct to medications.

FRONTIERS IN PAIN RESEARCH (2022)

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Correction Clinical Neurology

GBD 2016 Headache Collaborators. Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 (vol 17, pg 954, 2018)

Ali H. Mokdad

LANCET NEUROLOGY (2021)

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Review Clinical Neurology

Nerivio(R) remote electrical neuromodulation for acute treatment of chronic migraine

Hida Nierenburg et al.

Summary: Nerivio is a wearable Bluetooth device controlled by a smartphone app, approved by the US FDA for treating migraine in individuals aged 12 and older. Clinical trials and real-world studies have demonstrated the safety, tolerability, and efficacy of Nerivio as a nonmedication option for migraine treatment.

PAIN MANAGEMENT (2021)

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Article Clinical Neurology

Remote electrical neuromodulation for acute treatment of migraine in adolescents

Andrew D. Hershey et al.

Summary: The study suggests that REN may provide a safe and effective non-pharmacological alternative for acute treatment in adolescents, addressing the limitations and side effects associated with pharmaceutical treatments.

HEADACHE (2021)

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Article Medicine, General & Internal

Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial

Robert Croop et al.

Summary: Rimegepant was found to be effective for preventive treatment of migraine compared to placebo, with tolerability similar to that of placebo and no unexpected or serious safety issues noted.

LANCET (2021)

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Review Clinical Neurology

Conditioned pain modulation-A comprehensive review

Shankar Ramaswamy et al.

Summary: Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the descending pain pathway, which could potentially serve as a biomarker for pain. Various factors influence CPM paradigms, including patient-related factors and methodological variables, highlighting the importance of establishing consistent methodologies for measuring CPM to enhance its robustness.

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY (2021)

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Article Clinical Neurology

CGRP monoclonal antibodies in migraine: an efficacy and tolerability comparison with standard prophylactic drugs

Fenne Vandervorst et al.

Summary: The new class of migraine preventive drugs, monoclonal antibodies targeting the CGRP pathway, demonstrates efficacy comparable to or higher than currently used preventive drugs, supported by robust evidence from large randomized clinical trials. Their excellent tolerability and emerging long-term safety data suggest an unprecedented efficacy-over-adverse-effect profile, adding value to migraine prevention.

JOURNAL OF HEADACHE AND PAIN (2021)

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Article Clinical Neurology

Guidelines of the International Headache Society for clinical trials with neuromodulation devices for the treatment of migraine

Cristina Tassorelli et al.

Summary: The International Headache Society's Clinical Trials Committee has provided recommendations for optimizing the design and conduct of controlled trials of neuromodulation devices for the acute and/or preventive treatment of migraine. This includes defining key terms, providing recommendations for assessment in different age groups, outlining ethical and administrative responsibilities, and creating a bibliography of previous research in this area. Adopting these recommendations will improve the quality of evidence regarding the use of neuromodulation devices in migraine treatment.

CEPHALALGIA (2021)

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Review Medicine, General & Internal

Migraine: integrated approaches to clinical management and emerging treatments

Messoud Ashina et al.

Summary: Migraine is a highly disabling neurological disorder affecting over 1 billion people worldwide. Treatment options include pharmacological and non-pharmacological therapies. Building a personalized treatment plan and exploring emerging mechanism-based treatments are crucial for effective management.

LANCET (2021)

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Article Clinical Neurology

The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice

Jessica Ailani et al.

Summary: This update aims to incorporate recent research findings, expert consensus, and patient perspectives into updated guidance on the use of new acute and preventive treatments for migraine in adults. It provides practical recommendations based on expanded evidence base and emerging expert consensus, in the absence of a formal guideline.

HEADACHE (2021)

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Review Medicine, General & Internal

Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis

Juliana H. VanderPluym et al.

Summary: This study found that multiple acute treatments for migraine were associated with improvements in short-term pain outcomes, but evidence for interventions such as opioids was limited.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

Atogepant for the Preventive Treatment of Migraine

Jessica Ailani et al.

Summary: Oral atogepant once daily was effective in reducing the number of migraine days and headache days over a period of 12 weeks, but may cause adverse events such as constipation and nausea. Longer and larger trials are needed to determine the effect and safety of atogepant for migraine prevention.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Clinical Neurology

Remote Electrical Neuromodulation (REN) for the Acute Treatment of Menstrual Migraine: a Retrospective Survey Study of Effectiveness and Tolerability

Hida Nierenburg et al.

Summary: The study found that approximately 75% of participants reported that REN treatment was at least moderately effective, 45% reported satisfaction, and all participants reported that the treatment was at least moderately tolerable. Thirteen percent of respondents reported mild short-term side effects.

PAIN AND THERAPY (2021)

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Article Neurosciences

Safety and efficacy of remote electrical neuromodulation for the acute treatment of chronic migraine: an open-label study

Brian Grosberg et al.

Summary: The study demonstrates that REN has a positive effect on nausea, photophobia, and phonophobia, while also improving functional ability. Remote electrical neuromodulation treatment provides relief for migraine headaches and associated symptoms, offering a drug-free acute treatment option for those with chronic migraine.

PAIN REPORTS (2021)

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Article Neurosciences

Safety and efficacy of remote electrical neuromodulation for the acute treatment of chronic migraine: an open-label study

Brian Grosberg et al.

Summary: The efficacy of remote electrical neuromodulation (REN) in treating chronic migraine was validated in a study with a large sample size. Results showed that REN provided pain relief and disappearance, along with improvement in associated symptoms and functional ability. This drug-free acute treatment option offers a favorable treatment for people with chronic migraine.

PAIN REPORTS (2021)

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Article Clinical Neurology