Metal-free and site-selective α-C-H functionalization of tetrahydrofuran enabled by the photocatalytic generation of bromine radicals

The first example of using commercially available and cheap (Bu4NBr)-Bu-n as a cocatalyst, which is photoactivated by 4-CzIPN, to selectively activate the alpha-C-H bond of tetrahydrofuran for C-S and C-C cross-couplings is reported herein. This transition-metal free strategy features operational simplicity, mild and inherent green conditions as well as broad substrate scope.

Automated summary

This study reports a novel approach using commercially available and cheap (Bu4NBr)-Bu-n as a cocatalyst, photoactivated by 4-CzIPN, to selectively activate the alpha-C-H bond of tetrahydrofuran for C-S and C-C cross-couplings. This transition-metal free strategy offers simplicity in operation, mild and environmentally friendly conditions, and a wide range of substrates.