4.3 Article

Study of effect modifiers of genetically predicted CETP reduction

Related references

Note: Only part of the references are listed.
Article Public, Environmental & Occupational Health

Avoiding collider bias in Mendelian randomization when performing stratified analyses

Claudia Coscia et al.

Summary: The study introduces a new method for Mendelian randomization (MR) that uses residual collider variables in population strata to estimate causality without collider bias, allowing for investigating heterogeneity among subgroups of the population.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2022)

Article Biochemistry & Molecular Biology

Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial

Stephen J. Nicholls et al.

Summary: In a randomized clinical trial, obicetrapib, a CETP inhibitor, was found to effectively lower LDL-C levels when used in conjunction with high-intensity statins. The treatment also improved other lipid measurements and showed a favorable safety profile. These results indicate the potential of obicetrapib in addressing the medical needs of high-cardiovascular-risk patients.

NATURE MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

Florian Kronenberg et al.

Summary: This consensus statement provides updated evidence on the role of Lp(a) in ASCVD and aortic valve stenosis, and offers clinical guidance on testing and treating elevated Lp(a) levels.

EUROPEAN HEART JOURNAL (2022)

Article Biology

A sex-specific evolutionary interaction between ADCY9 and CETP

Isabel Gamache et al.

Summary: Pharmacogenomic studies have identified associations between ADCY9 and CETP genes in recent human evolution, potentially due to sex-specific selection, pointing towards a biological link between dalcetrapib's pharmacogene ADCY9 and its therapeutic target CETP.

ELIFE (2021)

Article Genetics & Heredity

Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank

Joseph D. Szustakowski et al.

Summary: The UK Biobank Exome Sequencing Consortium is a successful collaborative project between UK Biobank and biopharmaceutical companies, providing valuable rare coding variation resources for drug discovery. The project has strengthened academic and industry ties and promoted interaction and learning within the wider research community.

NATURE GENETICS (2021)

Article Biochemistry & Molecular Biology

Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage

Lahoucine Izem et al.

JOURNAL OF LIPID RESEARCH (2020)

Article Multidisciplinary Sciences

Evaluating drug targets through human loss-of-function genetic variation

Eric Vallabh Minikel et al.

NATURE (2020)

Article Multidisciplinary Sciences

Genetic drug target validation using Mendelian randomisation

Amand F. Schmidt et al.

NATURE COMMUNICATIONS (2020)

Article Cardiac & Cardiovascular Systems

Effect of Anacetrapib on Cholesterol Efflux Capacity: A Substudy of the DEFINE Trial

Mark P. Metzinger et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

Article Biochemistry & Molecular Biology

Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile

Lisanne L. Blauw et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2019)

Article Biochemistry & Molecular Biology

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

Johannes Kettunen et al.

PLOS BIOLOGY (2019)

Review Public, Environmental & Occupational Health

Women in clinical trials: a review of policy development and health equity in the Canadian context

Alla Yakerson

INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH (2019)

Article Medicine, General & Internal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Medicine, General & Internal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Cardiac & Cardiovascular Systems

Variants at the APOE/C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High-Density Lipoprotein Cholesterol

Cecile Low-Kam et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

Article Multidisciplinary Sciences

The UK Biobank resource with deep phenotyping and genomic data

Clare Bycroft et al.

NATURE (2018)

Article Cardiac & Cardiovascular Systems

CETP (Cholesteryl Ester Transfer Protein) Concentration A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease

Lisanne L. Blauw et al.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2018)

Article Medicine, General & Internal

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

Brian A. Ference et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Article Medicine, General & Internal

Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

A. Michael Lincoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Serum CETP concentration is not associated with measures of body fat: The NEO study

Lisanne L. Blauw et al.

ATHEROSCLEROSIS (2016)

Article Cardiac & Cardiovascular Systems

Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation Concordance With Clinical Outcomes

Jean-Claude Tardif et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2016)

Article Multidisciplinary Sciences

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

Johannes Kettunen et al.

NATURE COMMUNICATIONS (2016)

Article Cardiac & Cardiovascular Systems

Genotype-Dependent Effects of Dalcetrapib on Cholesterol Efflux and Inflammation Concordance With Clinical Outcomes

Jean-Claude Tardif et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2016)

Article Gastroenterology & Hepatology

Plasma Cholesteryl Ester Transfer Protein Is Predominantly Derived From Kupffer Cells

Yanan Wang et al.

HEPATOLOGY (2015)

Article Genetics & Heredity

The support of human genetic evidence for approved drug indications

Matthew R. Nelson et al.

NATURE GENETICS (2015)

Article Biochemistry & Molecular Biology

Adiposity significantly modifies genetic risk for dyslipidemia

Christopher B. Cole et al.

JOURNAL OF LIPID RESEARCH (2014)

Article Hematology

Genetic Determination of Plasma Cholesterol Efflux Capacity Is Gender-Specific and Independent of HDL-Cholesterol Levels

Elise F. Villard et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Article Medicine, General & Internal

Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome

Gregory G. Schwartz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis

Amit V. Khera et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Cardiac & Cardiovascular Systems

Representation of Women in Randomized Clinical Trials of Cardiovascular Disease Prevention

Chiara Melloni et al.

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES (2010)

Article Medicine, General & Internal

Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease.

Christopher P. Cannon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Biochemistry & Molecular Biology

Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia

Katherine K. Anagnostopoulou et al.

LIPIDS IN HEALTH AND DISEASE (2009)

Article Biochemistry & Molecular Biology

Cellular SR-BI and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects

Giovanna Catalano et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Possible role for intracellular cholesteryl ester transfer protein in adipocyte lipid metabolism and storage

Lahoucine Izem et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Medicine, General & Internal

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

JC Cohen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)