Effectiveness of targeting the NLRP3 inflammasome by using natural polyphenols: A systematic review of implications on health effects

Globally, inflammation and metabolic disorders pose serious public health problems and are major health concerns. It has been shown that natural polyphenols are effective in the treatment of metabolic diseases, including anti-inflammation, anti-diabetes, anti-obesity, neuron-protection, and cardio-protection. NLRP3 inflammasome, which are multiprotein complexes located within the cytosol, play an important role in the innate immune system. However, aberrant activation of the NLRP3 inflammasome were discovered as essential mo-lecular mechanisms in triggering inflammatory processes as well as implicating it in several major metabolic diseases, such as type 2 diabetes mellitus, obesity, atherosclerosis or cardiovascular disease. Recent studies indicate that natural polyphenols can inhibit NLRP3 inflammasome activation. In this review, the progress of natural polyphenols preventing inflammation and metabolic disorders via targeting NLRP3 inflammasome is systemically summarized. From the viewpoint of interfering NLRP3 inflammasome activation, the health effects of natural polyphenols are explained. Recent advances in other beneficial effects, clinical trials, and nano -delivery systems for targeting NLRP3 inflammasome are also reviewed. NLRP3 inflammasome is targeted by natural polyphenols to exert multiple health effects, which broadens the understanding of polyphenol mecha-nisms and provides valuable guidance to new researchers in this field.

Automated summary

Globally, inflammation and metabolic disorders are significant public health concerns, and natural polyphenols have shown effectiveness in treating these conditions. The NLRP3 inflammasome, a complex within the cytosol, plays a crucial role in the innate immune system, but its aberrant activation is implicated in inflammatory processes and major metabolic diseases. Recent studies have demonstrated that natural polyphenols can inhibit NLRP3 inflammasome activation, providing potential therapeutic benefits for inflammation and metabolic disorders. This review summarizes the progress in understanding the mechanisms by which natural polyphenols target the NLRP3 inflammasome and explores their broader health effects.