The Immunologic Profiles of Kawasaki Disease Triggered by Mycoplasma pneumoniae Infection

Article Pathology

Epidemiology and Clinical Characteristics of Henoch-Schonlein Purpura Associated with Streptococcal Infection in 217 Children in Hubei Province, China

Xiao-peng Shang et al.

Summary: The study found that streptococcal infection is one of the most common pathogens causing HSP in children, with certain epidemiological characteristics, and can cause renal involvement and affect immune function.

FETAL AND PEDIATRIC PATHOLOGY (2022)

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Article Pediatrics

Profile of Children with Kawasaki Disease Associated with Tropical Infections

Akanksha Mahajan et al.

Summary: Kawasaki disease in India has been linked to various infectious triggers such as dengue, chikungunya, COVID-19, hepatitis A, etc. It is important to consider KD in febrile patients with mucocutaneous involvement or in cases of nonresponsive sepsis despite adequate therapy.

INDIAN JOURNAL OF PEDIATRICS (2022)

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Article Medical Laboratory Technology

Serum amyloid a, C-reactive protein, and procalcitonin levels in children with Mycoplasma pneumoniae infection

Yuanyuan Jiang et al.

Summary: This study analyzed serum markers and immunoglobulin levels in children with Mycoplasma pneumoniae (MP) infection and evaluated their diagnostic value in differentiating MP infection. The results showed that serum amyloid A, C-reactive protein, and procalcitonin are specific markers for the early diagnosis of MP infection in children.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Review Medicine, General & Internal

Mycoplasma pneumoniae Infections and Primary Immune Deficiencies

Dimitri Poddighe et al.

Summary: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in children and can also lead to extrapulmonary diseases. Children with primary immunodeficiencies, especially those with humoral immune deficiencies, may experience persistent or severe infections caused by M. pneumoniae. Actively searching for M. pneumoniae infection may be beneficial, particularly in children with humoral immune deficiencies.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2022)

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Article Immunology

Increased CD8+T cells in patients with Henoch-Schonlein purpura nephritis exhibit suppressive immune activity

Zhao Fengyong et al.

Summary: Peripheral CD8+ T cells were significantly increased in HSPN patients, accompanied by decreased CD69 expression and cytokine secretion. The expression of CD69 in CD3+, CD4+, and CD8+ T cells was significantly negatively correlated with renal function indicators.

IMMUNOLOGY LETTERS (2022)

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Article Pediatrics

Neonatal sepsis and Kawasaki disease

Akihito Takeuchi et al.

Summary: The purpose of this study is to clarify the relationship between neonatal sepsis and future development of Kawasaki disease (KD). The study found that among infants admitted to the NICU, neonatal sepsis is associated with a higher likelihood of developing KD at 3 years of age.

EUROPEAN JOURNAL OF PEDIATRICS (2022)

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Article Pediatrics

Complement 3 and the Prognostic Nutritional Index Distinguish Kawasaki Disease from Other Fever Illness with a Nomogram

Yi-Shuang Huang et al.

Summary: This study aimed to establish a model to distinguish Kawasaki disease from other fever illnesses using prognostic nutritional index (PNI) and immunological factors. Patients with Kawasaki disease showed increased levels of C3 and decreased nutritional index compared to children with febrile diseases. The nomogram established with these factors effectively identified Kawasaki disease from febrile illness in children.

CHILDREN-BASEL (2021)

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Review Rheumatology

Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison

Chetan Sharma et al.

Summary: Children and adolescents infected with SARS-CoV-2 often exhibit mild symptoms, but may also develop a pediatric systemic vasculitis called MIS-C. This condition shares features with myocarditis and Kawasaki disease. Research indicates that MIS-C is a result of an exaggerated immune response triggered by prior exposure to SARS-CoV-2.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Genetics & Heredity

Diagnostic Value of Immune-Related Genes in Kawasaki Disease

Dong Liu et al.

Summary: Kawasaki disease predominantly damages medium- and small-sized vessels, mainly causing coronary artery lesions. The diagnostic markers of KD are immune-related genes, and the proportions of immune cells in KD patients differ from those in the non-KD group.

FRONTIERS IN GENETICS (2021)

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Article Hematology

Epidemiology and Clinical Characteristics of Henoch-Schonlein Purpura Associated with Epstein-Barr Virus Infection

Hong-bo Hu et al.

Summary: EBV infection may increase the incidence of HSP, lead to higher frequency of abdominal pain, disrupt the balance of cellular and humoral immune system, resulting in increased production of inflammatory mediators and immunoglobulins.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2021)

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Article Pediatrics

Immunological Features of Pediatric Interstitial Pneumonia Due to Mycoplasma pneumoniae

Xuefeng Xu et al.

Summary: The study analyzed the immunological features of pediatric interstitial pneumonia caused by Mycoplasma pneumoniae infections. Results showed that higher CD4(+) T cell counts and lower serum IFN-γ levels were associated with the development of interstitial pneumonia in children with M. pneumoniae. Specific immunologic profiles may play a role in the pathogenesis of pediatric interstitial pneumonia due to M. pneumoniae infections.

FRONTIERS IN PEDIATRICS (2021)

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Letter Hematology

Epidemiology and Clinical Characteristics of Henoch-Schonlein Purpura Associated with Mycoplasma pneumoniae Infection in 131 Children in Hubei Province, China

Xiao-peng Shang et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2021)

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Article Immunology

Five immune-gene-signatures participate in the development and pathogenesis of Kawasaki disease

Han Nie et al.

Summary: The study aimed to identify immune genes important in Kawasaki disease and investigate its pathogenesis through bioinformatics analysis. Immune cell infiltration analysis revealed differences in immune cell expression between normal and Kawasaki disease samples, and key genes such as CXCL8, CCL5, CCR7, CXCR3, and CCR1 were identified as potentially playing significant roles in the development of Kawasaki disease.

IMMUNITY INFLAMMATION AND DISEASE (2021)

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Article Medical Laboratory Technology