Fresh vs. frozen embryo transfer: new approach to minimize the limitations of using national surveillance data for clinical research

Article Obstetrics & Gynecology

Comparison of perinatal outcomes after frozen or fresh embryo transfer: separate analyses of singleton, twin , and sibling live births from a linked national in vitro fertilization registry

Edwin-Amalraj Raja et al.

Summary: This population-based retrospective cohort study compares the perinatal outcomes between frozen and fresh embryo transfer (ET) in singletons, sets of twins, and siblings. The study found that frozen ET is associated with a lower risk of preterm birth, low birthweight, and congenital anomalies in singletons and twins. However, there is a higher risk of high birthweight and being large for gestational age. Singletons conceived following frozen ET have a lower risk of low birthweight and being small for gestational age compared to a singleton sibling born after fresh ET. Overall, frozen ET appears to have both advantages and disadvantages in perinatal outcomes.

FERTILITY AND STERILITY (2022)

Add to Collection

Article Obstetrics & Gynecology

Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers

Paul Pirtea et al.

Summary: The study retrospectively analyzed data from 4,429 women and found that the true recurrent implantation failure rate is low. For patients capable of producing euploid blastocysts, transferring three embryos can still achieve a high clinical pregnancy rate.

FERTILITY AND STERILITY (2021)

Add to Collection

Article Obstetrics & Gynecology

Transfer of fresh or frozen embryos: a randomised controlled tria

K. M. Wong et al.

Summary: A study in the Netherlands compared the freeze-all strategy with the conventional strategy in IVF treatments, and found that the conventional strategy had a higher cumulative ongoing pregnancy rate per woman. However, further research is needed to determine the efficacy of the freeze-all strategy in different patient subgroups and embryonic development stages, and to weigh the potential benefits and risks for mothers and children.

HUMAN REPRODUCTION (2021)

Add to Collection

Article Genetics & Heredity

Utilization of preimplantation genetic testing in the USA

Kaitlyn Roche et al.

Summary: The study found a significant increase in the number of preimplantation genetic testing (PGT) cycles from 2014 to 2017 in the USA, with a higher percentage of PGT treatment cycles among younger women compared to older women. Both PGT and non-PGT cycles showed a significant decrease in live birth rates from 2014 to 2017.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

Add to Collection

Review Obstetrics & Gynecology