Journal
FEBS JOURNAL
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/febs.16704
Keywords
3D models; metabolic heterogeneity; metabolic sensors; tissue culture media; tumour cell metabolism
Categories
Funding
- Rennes Metropole [R20167NN]
- ATIP/Avenir program
- Canceropple Lyon Auvergne Rhpne Alpes [CVPPRCAN000174, CVPPRCAB000180, CV-2021-039]
- Region Auvergne Rhone-Alpes [19 010898 01]
- programs Projets Fondation ARC [R16173CC]
- Ligue Nationale contre le Cancer [R17167CC, R19007CC]
- Institut Convergence Francois Rabelais (PLASCAN BioMHet, MiStiM'Plast) [17IA66ANR-PLASCAN-MEHLEN]
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Advances in cancer biology have revealed that there are differences in cancer cell metabolism between in vitro and in vivo conditions. Current methodologies and tools can bridge this gap and generate new opportunities for effective therapies.
Advances in cancer biology over the past decades have revealed that metabolic adaptation of cancer cells is an essential aspect of tumorigenesis. However, recent insights into tumour metabolism in vivo have revealed dissimilarities with results obtained in vitro. This is partly due to the reductionism of in vitro cancer models that struggle to reproduce the complexity of tumour tissues. This review describes some of the discrepancies in cancer cell metabolism between in vitro and in vivo conditions, and presents current methodological approaches and tools used to bridge the gap with the clinically relevant microenvironment. As such, these approaches should generate new knowledge that could be more effectively translated into therapeutic opportunities.
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