Journal
EXPERT OPINION ON DRUG SAFETY
Volume 22, Issue 1, Pages 43-58Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14740338.2023.2173171
Keywords
Psoriasis; elderly; geriatric; treatment; biologics; small molecules
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The management of moderate-to-severe forms of psoriasis in elderly patients is a frequent concern due to the higher risk of adverse events, logistic issues, and comorbidities. Traditional systemic treatments are often contraindicated, making biologic drugs and small molecules a valuable option. However, data on their effectiveness and safety in elderly patients are limited.
IntroductionThe management of moderate-to-severe forms of psoriasis is becoming a frequent concern in geriatric age due to the higher risk to develop treatment adverse events, logistic issues, vulnerability to immune-related diseases and cancer, presence of comorbidities and the risk of drug interactions. In this context, traditional systemic treatments are often contraindicated, and biologic drugs and small molecules seem to be a valuable option. However, data on their effectiveness and safety in elderly patients are scant.Areas coveredThe aim of this review is to analyze the current literature in order to point out data on the efficacy and safety of biologic drugs and small molecules for the management of psoriasis in elderly patients in order to put the basis for universally shared treatment algorithm following available evidence. Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used for the literature research.Expert Opinion/CommentaryOur review suggests biologics and small molecules as an effective and safe option for the management of moderate-to-severe forms of psoriasis in elderly patients.
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