Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 19, Issue 12, Pages 1725-1734Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17425247.2022.2147504
Keywords
basal insulin; continuous glucose monitoring; fasting glucose variability; needle-free insulin injection; type 2 diabetes mellitus
Categories
Funding
- National Natural Science Foundation of China
- Top Talent Fund of Tangdu Hospital [82070839]
- Key Projects of Shaanxi Provincial Basic Research Program
- National Key RD Program [2020JZ-31]
- [2017YFC1309803]
- [2017YFC1309804]
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This study found that using a needle-free insulin injector (NFII) to administer basal insulin improved fasting glucose variability (FGV) in patients with type 2 diabetes mellitus (T2DM), as compared to conventional insulin pen (CIP) injection.
Background: Fasting glucose variability (FGV) extensively promotes the onset and development of diabetic complications. This study aimed to evaluate the FGV in type 2 diabetes mellitus (T2DM) patients administered basal insulin using a needle-free insulin injector (NFII). Research design and methods: This was a prospective randomized multicenter open-label crossover study. We randomly assigned 48 T2DM patients to receive basal insulin by NFII or conventional insulin pen (CIP) for 7-14 days and were then crossed over after washout. We conducted continuous glucose monitoring to investigate the FGV, our primary outcome was a composite parameter of the FGV with a fasting blood glucose target between 4.4 and 6.1 mmol/L. Results: The coefficient of variation for sensor glucose at 6 a.m. with CIP was 11.67 (8.70,14.81)% vs. 9.48 (6.48,12.24)% with NFII (p = 0.003), and the coefficient of variation for mean sensor glucose at 5-6 a.m. with CIP was 12.70 (9.17,16.56)% vs. 9.23 (7.01,11.98)% with NFII (p < 0.001). The overall basal insulin dosage with CIP injection was 18.00 (16.00, 20.00) IU vs. 16.00 (12.00, 19.00) IU during NFII (p < 0.003). Conclusion: Compared with CIP, the use of the NFII to inject basal insulin improved FGV in T2DM.
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